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Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors possessing augmented P2' side chains.
Smith AB 3rd, Charnley AK, Harada H, Beiger JJ, Cantin LD, Kenesky CS, Hirschmann R, Munshi S, Olsen DB, Stahlhut MW, Schleif WA, Kuo LC. Smith AB 3rd, et al. Among authors: cantin ld. Bioorg Med Chem Lett. 2006 Feb 15;16(4):859-63. doi: 10.1016/j.bmcl.2005.11.011. Epub 2005 Nov 18. Bioorg Med Chem Lett. 2006. PMID: 16298527
PDE-10A inhibitors as insulin secretagogues.
Cantin LD, Magnuson S, Gunn D, Barucci N, Breuhaus M, Bullock WH, Burke J, Claus TH, Daly M, Decarr L, Gore-Willse A, Hoover-Litty H, Kumarasinghe ES, Li Y, Liang SX, Livingston JN, Lowinger T, Macdougall M, Ogutu HO, Olague A, Ott-Morgan R, Schoenleber RW, Tersteegen A, Wickens P, Zhang Z, Zhu J, Zhu L, Sweet LJ. Cantin LD, et al. Bioorg Med Chem Lett. 2007 May 15;17(10):2869-73. doi: 10.1016/j.bmcl.2007.02.061. Epub 2007 Feb 25. Bioorg Med Chem Lett. 2007. PMID: 17400452
Discovery of P2X3 selective antagonists for the treatment of chronic pain.
Cantin LD, Bayrakdarian M, Buon C, Grazzini E, Hu YJ, Labrecque J, Leung C, Luo X, Martino G, Paré M, Payza K, Popovic N, Projean D, Santhakumar V, Walpole C, Yu XH, Tomaszewski MJ. Cantin LD, et al. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2565-71. doi: 10.1016/j.bmcl.2012.01.124. Epub 2012 Feb 9. Bioorg Med Chem Lett. 2012. PMID: 22370269
Indanylacetic acid derivatives carrying aryl-pyridyl and aryl-pyrimidinyl tail groups--new classes of PPAR gamma/delta and PPAR alpha/gamma/delta agonists.
Cantin LD, Liang S, Ogutu H, Iwuagwu CI, Boakye K, Bullock WH, Burns M, Clark R, Claus T, delaCruz FE, Daly M, Ehrgott FJ, Johnson JS, Keiper C, Livingston JN, Schoenleber RW, Shapiro J, Town C, Yang L, Tsutsumi M, Ma X. Cantin LD, et al. Bioorg Med Chem Lett. 2007 Feb 15;17(4):1056-61. doi: 10.1016/j.bmcl.2006.11.025. Epub 2006 Nov 15. Bioorg Med Chem Lett. 2007. PMID: 17157013
Indanylacetic acids as PPAR-delta activator insulin sensitizers.
Wickens P, Zhang C, Ma X, Zhao Q, Amatruda J, Bullock W, Burns M, Cantin LD, Chuang CY, Claus T, Dai M, Dela Cruz F, Dickson D, Ehrgott FJ, Fan D, Heald S, Hentemann M, Iwuagwu CI, Johnson JS, Kumarasinghe E, Ladner D, Lavoie R, Liang S, Livingston JN, Lowe D, Magnuson S, Mannelly G, Mugge I, Ogutu H, Pleasic-Williams S, Schoenleber RW, Shapiro J, Shelekhin T, Sweet L, Town C, Tsutsumi M. Wickens P, et al. Among authors: cantin ld. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4369-73. doi: 10.1016/j.bmcl.2007.03.057. Epub 2007 Mar 23. Bioorg Med Chem Lett. 2007. PMID: 17601734
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