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Mig-6 controls EGFR trafficking and suppresses gliomagenesis.
Ying H, Zheng H, Scott K, Wiedemeyer R, Yan H, Lim C, Huang J, Dhakal S, Ivanova E, Xiao Y, Zhang H, Hu J, Stommel JM, Lee MA, Chen AJ, Paik JH, Segatto O, Brennan C, Elferink LA, Wang YA, Chin L, DePinho RA. Ying H, et al. Among authors: xiao y. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6912-7. doi: 10.1073/pnas.0914930107. Epub 2010 Mar 29. Proc Natl Acad Sci U S A. 2010. PMID: 20351267 Free PMC article.
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.
Kimmelman AC, Hezel AF, Aguirre AJ, Zheng H, Paik JH, Ying H, Chu GC, Zhang JX, Sahin E, Yeo G, Ponugoti A, Nabioullin R, Deroo S, Yang S, Wang X, McGrath JP, Protopopova M, Ivanova E, Zhang J, Feng B, Tsao MS, Redston M, Protopopov A, Xiao Y, Futreal PA, Hahn WC, Klimstra DS, Chin L, DePinho RA. Kimmelman AC, et al. Among authors: xiao y. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19372-7. doi: 10.1073/pnas.0809966105. Epub 2008 Dec 2. Proc Natl Acad Sci U S A. 2008. PMID: 19050074 Free PMC article.
PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas.
Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA. Zheng H, et al. Among authors: xiao y. Cancer Cell. 2010 May 18;17(5):497-509. doi: 10.1016/j.ccr.2010.03.020. Cancer Cell. 2010. PMID: 20478531 Free PMC article.
PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network.
Ying H, Elpek KG, Vinjamoori A, Zimmerman SM, Chu GC, Yan H, Fletcher-Sananikone E, Zhang H, Liu Y, Wang W, Ren X, Zheng H, Kimmelman AC, Paik JH, Lim C, Perry SR, Jiang S, Malinn B, Protopopov A, Colla S, Xiao Y, Hezel AF, Bardeesy N, Turley SJ, Wang YA, Chin L, Thayer SP, DePinho RA. Ying H, et al. Among authors: xiao y. Cancer Discov. 2011 Jul;1(2):158-69. doi: 10.1158/2159-8290.CD-11-0031. Epub 2011 May 23. Cancer Discov. 2011. PMID: 21984975 Free PMC article.
Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases.
Ding Z, Wu CJ, Jaskelioff M, Ivanova E, Kost-Alimova M, Protopopov A, Chu GC, Wang G, Lu X, Labrot ES, Hu J, Wang W, Xiao Y, Zhang H, Zhang J, Zhang J, Gan B, Perry SR, Jiang S, Li L, Horner JW, Wang YA, Chin L, DePinho RA. Ding Z, et al. Among authors: xiao y. Cell. 2012 Mar 2;148(5):896-907. doi: 10.1016/j.cell.2012.01.039. Epub 2012 Feb 16. Cell. 2012. PMID: 22341455 Free PMC article.
microRNA regulatory network inference identifies miR-34a as a novel regulator of TGF-β signaling in glioblastoma.
Genovese G, Ergun A, Shukla SA, Campos B, Hanna J, Ghosh P, Quayle SN, Rai K, Colla S, Ying H, Wu CJ, Sarkar S, Xiao Y, Zhang J, Zhang H, Kwong L, Dunn K, Wiedemeyer WR, Brennan C, Zheng H, Rimm DL, Collins JJ, Chin L. Genovese G, et al. Among authors: xiao y. Cancer Discov. 2012 Aug;2(8):736-49. doi: 10.1158/2159-8290.CD-12-0111. Epub 2012 Jun 29. Cancer Discov. 2012. PMID: 22750848 Free PMC article.
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression.
Ding Z, Wu CJ, Chu GC, Xiao Y, Ho D, Zhang J, Perry SR, Labrot ES, Wu X, Lis R, Hoshida Y, Hiller D, Hu B, Jiang S, Zheng H, Stegh AH, Scott KL, Signoretti S, Bardeesy N, Wang YA, Hill DE, Golub TR, Stampfer MJ, Wong WH, Loda M, Mucci L, Chin L, DePinho RA. Ding Z, et al. Among authors: xiao y. Nature. 2011 Feb 10;470(7333):269-73. doi: 10.1038/nature09677. Epub 2011 Feb 2. Nature. 2011. PMID: 21289624 Free PMC article.
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.
Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, DePinho RA. Ying H, et al. Among authors: xiao y. Cell. 2012 Apr 27;149(3):656-70. doi: 10.1016/j.cell.2012.01.058. Cell. 2012. PMID: 22541435 Free PMC article.
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