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A novel orally available small molecule that inhibits hepatitis B virus expression.
Mueller H, Wildum S, Luangsay S, Walther J, Lopez A, Tropberger P, Ottaviani G, Lu W, Parrott NJ, Zhang JD, Schmucki R, Racek T, Hoflack JC, Kueng E, Point F, Zhou X, Steiner G, Lütgehetmann M, Rapp G, Volz T, Dandri M, Yang S, Young JAT, Javanbakht H. Mueller H, et al. J Hepatol. 2018 Mar;68(3):412-420. doi: 10.1016/j.jhep.2017.10.014. Epub 2017 Oct 25. J Hepatol. 2018. PMID: 29079285 Free article.
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Wat C, Gane E, Yuen MF, Pavlovic V, Mueller H, Krippendorff BF, Grippo JF, Ottosen S. Wat C, et al. Among authors: mueller h. Hepatology. 2022 Apr;75(4):1050-1051. doi: 10.1002/hep.32113. Epub 2021 Dec 13. Hepatology. 2022. PMID: 34396570 No abstract available.
Clinical Study of Single-Stranded Oligonucleotide RO7062931 in Healthy Volunteers and Patients With Chronic Hepatitis B.
Gane E, Yuen MF, Kim DJ, Chan HL, Surujbally B, Pavlovic V, Das S, Triyatni M, Kazma R, Grippo JF, Buatois S, Lemenuel-Diot A, Krippendorff BF, Mueller H, Zhang Y, Kim HJ, Leerapun A, Lim TH, Lim YS, Tanwandee T, Kim W, Cheng W, Hu TH, Wat C. Gane E, et al. Among authors: mueller h. Hepatology. 2021 Oct;74(4):1795-1808. doi: 10.1002/hep.31920. Epub 2021 Aug 25. Hepatology. 2021. PMID: 34037271 Free PMC article. Clinical Trial.
Liver-Targeted Anti-HBV Single-Stranded Oligonucleotides with Locked Nucleic Acid Potently Reduce HBV Gene Expression In Vivo.
Javanbakht H, Mueller H, Walther J, Zhou X, Lopez A, Pattupara T, Blaising J, Pedersen L, Albæk N, Jackerott M, Shi T, Ploix C, Driessen W, Persson R, Ravn J, Young JAT, Ottosen S. Javanbakht H, et al. Among authors: mueller h. Mol Ther Nucleic Acids. 2018 Jun 1;11:441-454. doi: 10.1016/j.omtn.2018.02.005. Epub 2018 Feb 23. Mol Ther Nucleic Acids. 2018. PMID: 29858079 Free PMC article.
Crystal structure of human homogentisate dioxygenase.
Titus GP, Mueller HA, Burgner J, Rodríguez De Córdoba S, Peñalva MA, Timm DE. Titus GP, et al. Among authors: mueller ha. Nat Struct Biol. 2000 Jul;7(7):542-6. doi: 10.1038/76756. Nat Struct Biol. 2000. PMID: 10876237
737 results