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Page 1
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T, Chan MC, Rydzik AM, Hopkinson RJ, Che KH, Daniel M, Strain-Damerell C, Gileadi C, Kochan G, Leung IK, Dunford J, Yeoh KK, Ratcliffe PJ, Burgess-Brown N, von Delft F, Muller S, Marsden B, Brennan PE, McDonough MA, Oppermann U, Klose RJ, Schofield CJ, Kawamura A. Rose NR, et al. Among authors: ratcliffe pj. J Med Chem. 2012 Jul 26;55(14):6639-43. doi: 10.1021/jm300677j. Epub 2012 Jul 11. J Med Chem. 2012. PMID: 22724510 Free PMC article.
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
Chowdhury R, Yeoh KK, Tian YM, Hillringhaus L, Bagg EA, Rose NR, Leung IK, Li XS, Woon EC, Yang M, McDonough MA, King ON, Clifton IJ, Klose RJ, Claridge TD, Ratcliffe PJ, Schofield CJ, Kawamura A. Chowdhury R, et al. Among authors: ratcliffe pj. EMBO Rep. 2011 May;12(5):463-9. doi: 10.1038/embor.2011.43. Epub 2011 Apr 1. EMBO Rep. 2011. PMID: 21460794 Free PMC article.
A photoreactive small-molecule probe for 2-oxoglutarate oxygenases.
Rotili D, Altun M, Kawamura A, Wolf A, Fischer R, Leung IKH, Mackeen MM, Tian YM, Ratcliffe PJ, Mai A, Kessler BM, Schofield CJ. Rotili D, et al. Among authors: ratcliffe pj. Chem Biol. 2011 May 27;18(5):642-654. doi: 10.1016/j.chembiol.2011.03.007. Chem Biol. 2011. PMID: 21609845 Free PMC article.
Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.
Yeoh KK, Chan MC, Thalhammer A, Demetriades M, Chowdhury R, Tian YM, Stolze I, McNeill LA, Lee MK, Woon ECY, Mackeen MM, Kawamura A, Ratcliffe PJ, Mecinović J, Schofield CJ. Yeoh KK, et al. Among authors: ratcliffe pj. Org Biomol Chem. 2013 Feb 7;11(5):732-745. doi: 10.1039/c2ob26648b. Epub 2012 Nov 15. Org Biomol Chem. 2013. PMID: 23151668 Free PMC article.
Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
Chowdhury R, Candela-Lena JI, Chan MC, Greenald DJ, Yeoh KK, Tian YM, McDonough MA, Tumber A, Rose NR, Conejo-Garcia A, Demetriades M, Mathavan S, Kawamura A, Lee MK, van Eeden F, Pugh CW, Ratcliffe PJ, Schofield CJ. Chowdhury R, et al. Among authors: ratcliffe pj. ACS Chem Biol. 2013 Jul 19;8(7):1488-96. doi: 10.1021/cb400088q. Epub 2013 Jun 12. ACS Chem Biol. 2013. PMID: 23683440
5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.
Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XS, Kristensen JBL, King ONF, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, Lejeune C, Rydzik AM, Rose NR, Bagg EA, McDonough MA, Krojer T, Yue WW, Ng SS, Olsen L, Brennan PE, Oppermann U, Muller-Knapp S, Klose RJ, Ratcliffe PJ, Schofield CJ, Kawamura A. Hopkinson RJ, et al. Among authors: ratcliffe pj. Chem Sci. 2013 Aug 1;4(8):3110-3117. doi: 10.1039/C3SC51122G. Chem Sci. 2013. PMID: 26682036 Free PMC article.
Oxygen sensing by HIF hydroxylases.
Schofield CJ, Ratcliffe PJ. Schofield CJ, et al. Among authors: ratcliffe pj. Nat Rev Mol Cell Biol. 2004 May;5(5):343-54. doi: 10.1038/nrm1366. Nat Rev Mol Cell Biol. 2004. PMID: 15122348 Review. No abstract available.
Signalling hypoxia by HIF hydroxylases.
Schofield CJ, Ratcliffe PJ. Schofield CJ, et al. Among authors: ratcliffe pj. Biochem Biophys Res Commun. 2005 Dec 9;338(1):617-26. doi: 10.1016/j.bbrc.2005.08.111. Epub 2005 Aug 24. Biochem Biophys Res Commun. 2005. PMID: 16139242 Review.
328 results