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Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host.
Salmon D, Vanwalleghem G, Morias Y, Denoeud J, Krumbholz C, Lhommé F, Bachmaier S, Kador M, Gossmann J, Dias FB, De Muylder G, Uzureau P, Magez S, Moser M, De Baetselier P, Van Den Abbeele J, Beschin A, Boshart M, Pays E. Salmon D, et al. Among authors: boshart m. Science. 2012 Jul 27;337(6093):463-6. doi: 10.1126/science.1222753. Epub 2012 Jun 14. Science. 2012. PMID: 22700656
Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA.
Gould MK, Bachmaier S, Ali JA, Alsford S, Tagoe DN, Munday JC, Schnaufer AC, Horn D, Boshart M, de Koning HP. Gould MK, et al. Among authors: boshart m. Antimicrob Agents Chemother. 2013 Oct;57(10):4882-93. doi: 10.1128/AAC.00508-13. Epub 2013 Jul 22. Antimicrob Agents Chemother. 2013. PMID: 23877697 Free PMC article.
Metabolic selection of a homologous recombination-mediated gene loss protects Trypanosoma brucei from ROS production by glycosomal fumarate reductase.
Wargnies M, Plazolles N, Schenk R, Villafraz O, Dupuy JW, Biran M, Bachmaier S, Baudouin H, Clayton C, Boshart M, Bringaud F. Wargnies M, et al. Among authors: boshart m. J Biol Chem. 2021 Jan-Jun;296:100548. doi: 10.1016/j.jbc.2021.100548. Epub 2021 Mar 17. J Biol Chem. 2021. PMID: 33741344 Free PMC article.
A multi-adenylate cyclase regulator at the flagellar tip controls African trypanosome transmission.
Bachmaier S, Giacomelli G, Calvo-Alvarez E, Vieira LR, Van Den Abbeele J, Aristodemou A, Lorentzen E, Gould MK, Brennand A, Dupuy JW, Forné I, Imhof A, Bramkamp M, Salmon D, Rotureau B, Boshart M. Bachmaier S, et al. Among authors: boshart m. Nat Commun. 2022 Sep 16;13(1):5445. doi: 10.1038/s41467-022-33108-z. Nat Commun. 2022. PMID: 36114198 Free PMC article.
Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in Trypanosoma brucei.
Bachmaier S, Gould MK, Polatoglou E, Omelianczyk R, Brennand AE, Aloraini MA, Munday JC, Horn D, Boshart M, de Koning HP. Bachmaier S, et al. Among authors: boshart m. Front Cell Infect Microbiol. 2023 Jul 5;13:1204707. doi: 10.3389/fcimb.2023.1204707. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37475965 Free PMC article.
81 results