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The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.
Cantó C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J. Cantó C, et al. Among authors: pirinen e. Cell Metab. 2012 Jun 6;15(6):838-47. doi: 10.1016/j.cmet.2012.04.022. Cell Metab. 2012. PMID: 22682224 Free PMC article.
Sirtuins as regulators of metabolism and healthspan.
Houtkooper RH, Pirinen E, Auwerx J. Houtkooper RH, et al. Among authors: pirinen e. Nat Rev Mol Cell Biol. 2012 Mar 7;13(4):225-238. doi: 10.1038/nrm3293. Nat Rev Mol Cell Biol. 2012. PMID: 22395773 Free PMC article. Review.
Mitochondrial sirtuins and metabolic homeostasis.
Pirinen E, Lo Sasso G, Auwerx J. Pirinen E, et al. Best Pract Res Clin Endocrinol Metab. 2012 Dec;26(6):759-70. doi: 10.1016/j.beem.2012.05.001. Epub 2012 May 31. Best Pract Res Clin Endocrinol Metab. 2012. PMID: 23168278 Free PMC article. Review.
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB. Kraus D, et al. Among authors: pirinen e. Nature. 2014 Apr 10;508(7495):258-62. doi: 10.1038/nature13198. Nature. 2014. PMID: 24717514 Free PMC article.
Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle.
Pirinen E, Cantó C, Jo YS, Morato L, Zhang H, Menzies KJ, Williams EG, Mouchiroud L, Moullan N, Hagberg C, Li W, Timmers S, Imhof R, Verbeek J, Pujol A, van Loon B, Viscomi C, Zeviani M, Schrauwen P, Sauve AA, Schoonjans K, Auwerx J. Pirinen E, et al. Cell Metab. 2014 Jun 3;19(6):1034-41. doi: 10.1016/j.cmet.2014.04.002. Epub 2014 May 8. Cell Metab. 2014. PMID: 24814482 Free PMC article.
Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis.
Verbeek J, Lannoo M, Pirinen E, Ryu D, Spincemaille P, Vander Elst I, Windmolders P, Thevissen K, Cammue BP, van Pelt J, Fransis S, Van Eyken P, Ceuterick-De Groote C, Van Veldhoven PP, Bedossa P, Nevens F, Auwerx J, Cassiman D. Verbeek J, et al. Among authors: pirinen e. Gut. 2015 Apr;64(4):673-83. doi: 10.1136/gutjnl-2014-306748. Epub 2014 Jun 10. Gut. 2015. PMID: 24917551
Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans.
van de Weijer T, Phielix E, Bilet L, Williams EG, Ropelle ER, Bierwagen A, Livingstone R, Nowotny P, Sparks LM, Paglialunga S, Szendroedi J, Havekes B, Moullan N, Pirinen E, Hwang JH, Schrauwen-Hinderling VB, Hesselink MK, Auwerx J, Roden M, Schrauwen P. van de Weijer T, et al. Among authors: pirinen e. Diabetes. 2015 Apr;64(4):1193-201. doi: 10.2337/db14-0667. Epub 2014 Oct 28. Diabetes. 2015. PMID: 25352640 Free PMC article. Clinical Trial.
66 results