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On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53.
Bista M, Smithson D, Pecak A, Salinas G, Pustelny K, Min J, Pirog A, Finch K, Zdzalik M, Waddell B, Wladyka B, Kedracka-Krok S, Dyer MA, Dubin G, Guy RK. Bista M, et al. Among authors: smithson d. PLoS One. 2012;7(6):e37518. doi: 10.1371/journal.pone.0037518. Epub 2012 Jun 4. PLoS One. 2012. PMID: 22675482 Free PMC article.
Identification and characterization of the first small molecule inhibitor of MDMX.
Reed D, Shen Y, Shelat AA, Arnold LA, Ferreira AM, Zhu F, Mills N, Smithson DC, Regni CA, Bashford D, Cicero SA, Schulman BA, Jochemsen AG, Guy RK, Dyer MA. Reed D, et al. Among authors: smithson dc. J Biol Chem. 2010 Apr 2;285(14):10786-96. doi: 10.1074/jbc.M109.056747. Epub 2010 Jan 15. J Biol Chem. 2010. PMID: 20080970 Free PMC article.
Podophyllotoxin analogues active versus Trypanosoma brucei.
Uddin MJ, Smithson DC, Brown KM, Crews BC, Connelly M, Zhu F, Marnett LJ, Guy RK. Uddin MJ, et al. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1787-91. doi: 10.1016/j.bmcl.2010.01.009. Epub 2010 Jan 11. Bioorg Med Chem Lett. 2010. PMID: 20129783 Free PMC article.
Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain.
Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR. Zhao Y, et al. Among authors: smithson dc. Biosci Rep. 2018 Jul 6;38(4):BSR20180231. doi: 10.1042/BSR20180231. Print 2018 Aug 31. Biosci Rep. 2018. PMID: 29472314 Free PMC article.
Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening.
Ortiz D, Guiguemde WA, Hammill JT, Carrillo AK, Chen Y, Connelly M, Stalheim K, Elya C, Johnson A, Min J, Shelat A, Smithson DC, Yang L, Zhu F, Guy RK, Landfear SM. Ortiz D, et al. Among authors: smithson dc. PLoS Negl Trop Dis. 2017 Dec 29;11(12):e0006157. doi: 10.1371/journal.pntd.0006157. eCollection 2017 Dec. PLoS Negl Trop Dis. 2017. PMID: 29287089 Free PMC article.
UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries.
Yang J, Liang Q, Wang M, Jeffries C, Smithson D, Tu Y, Boulos N, Jacob MR, Shelat AA, Wu Y, Ravu RR, Gilbertson R, Avery MA, Khan IA, Walker LA, Guy RK, Li XC. Yang J, et al. Among authors: smithson d. J Nat Prod. 2014 Apr 25;77(4):902-9. doi: 10.1021/np4009706. Epub 2014 Mar 11. J Nat Prod. 2014. PMID: 24617915 Free PMC article.
37 results