Darnell M - Search Results

1

An ex vivo perfusion system emulating in vivo conditions in noncirrhotic and cirrhotic human liver.

Schreiter T, Marquitan G, Darnell M, Sowa JP, Bröcker-Preuss M, Andersson TB, Baba HA, Furch M, Arteel GE, Mathé Z, Treckmann J, Gerken G, Gieseler RK, Canbay A. Schreiter T, et al. Among authors: darnell m. J Pharmacol Exp Ther. 2012 Sep;342(3):730-41. doi: 10.1124/jpet.112.194167. Epub 2012 Jun 6. J Pharmacol Exp Ther. 2012. PMID: 22674469 Free PMC article.

2

In vitro evaluation of major in vivo drug metabolic pathways using primary human hepatocytes and HepaRG cells in suspension and a dynamic three-dimensional bioreactor system.

Darnell M, Ulvestad M, Ellis E, Weidolf L, Andersson TB. Darnell M, et al. J Pharmacol Exp Ther. 2012 Oct;343(1):134-44. doi: 10.1124/jpet.112.195834. Epub 2012 Jul 9. J Pharmacol Exp Ther. 2012. PMID: 22776955

3

Evaluation of organic anion-transporting polypeptide 1B1 and CYP3A4 activities in primary human hepatocytes and HepaRG cells cultured in a dynamic three-dimensional bioreactor system.

Ulvestad M, Darnell M, Molden E, Ellis E, Åsberg A, Andersson TB. Ulvestad M, et al. Among authors: darnell m. J Pharmacol Exp Ther. 2012 Oct;343(1):145-56. doi: 10.1124/jpet.112.195750. Epub 2012 Jul 12. J Pharmacol Exp Ther. 2012. PMID: 22789711

4

Scaling down of a clinical three-dimensional perfusion multicompartment hollow fiber liver bioreactor developed for extracorporeal liver support to an analytical scale device useful for hepatic pharmacological in vitro studies.

Zeilinger K, Schreiter T, Darnell M, Söderdahl T, Lübberstedt M, Dillner B, Knobeloch D, Nüssler AK, Gerlach JC, Andersson TB. Zeilinger K, et al. Among authors: darnell m. Tissue Eng Part C Methods. 2011 May;17(5):549-56. doi: 10.1089/ten.TEC.2010.0580. Epub 2011 Feb 16. Tissue Eng Part C Methods. 2011. PMID: 21210724

5

Cytochrome P450-dependent metabolism in HepaRG cells cultured in a dynamic three-dimensional bioreactor.

Darnell M, Schreiter T, Zeilinger K, Urbaniak T, Söderdahl T, Rossberg I, Dillnér B, Berg AL, Gerlach JC, Andersson TB. Darnell M, et al. Drug Metab Dispos. 2011 Jul;39(7):1131-8. doi: 10.1124/dmd.110.037721. Epub 2011 Mar 24. Drug Metab Dispos. 2011. PMID: 21436404

6

Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacological in vitro studies.

Lübberstedt M, Müller-Vieira U, Biemel KM, Darnell M, Hoffmann SA, Knöspel F, Wönne EC, Knobeloch D, Nüssler AK, Gerlach JC, Andersson TB, Zeilinger K. Lübberstedt M, et al. Among authors: darnell m. J Tissue Eng Regen Med. 2015 Sep;9(9):1017-26. doi: 10.1002/term.1652. Epub 2012 Nov 20. J Tissue Eng Regen Med. 2015. PMID: 23165723

7

Investigation of the involvement of P-glycoprotein and multidrug resistance-associated protein 2 in the efflux of ximelagatran and its metabolites by using short hairpin RNA knockdown in Caco-2 cells.

Darnell M, Karlsson JE, Owen A, Hidalgo IJ, Li J, Zhang W, Andersson TB. Darnell M, et al. Drug Metab Dispos. 2010 Mar;38(3):491-7. doi: 10.1124/dmd.109.029967. Epub 2009 Dec 18. Drug Metab Dispos. 2010. PMID: 20023051

8

Metabolism of xenobiotic carboxylic acids: focus on coenzyme A conjugation, reactivity, and interference with lipid metabolism.

Darnell M, Weidolf L. Darnell M, et al. Chem Res Toxicol. 2013 Aug 19;26(8):1139-55. doi: 10.1021/tx400183y. Epub 2013 Jul 5. Chem Res Toxicol. 2013. PMID: 23790050 Review.

9

Significantly Different Covalent Binding of Oxidative Metabolites, Acyl Glucuronides, and S-Acyl CoA Conjugates Formed from Xenobiotic Carboxylic Acids in Human Liver Microsomes.

Darnell M, Breitholtz K, Isin EM, Jurva U, Weidolf L. Darnell M, et al. Chem Res Toxicol. 2015 May 18;28(5):886-96. doi: 10.1021/tx500514z. Epub 2015 Apr 8. Chem Res Toxicol. 2015. PMID: 25803559

10

Use of HμREL Human Coculture System for Prediction of Intrinsic Clearance and Metabolite Formation for Slowly Metabolized Compounds.

Hultman Ia, Vedin C, Abrahamsson A, Winiwarter S, Darnell M. Hultman Ia, et al. Among authors: darnell m. Mol Pharm. 2016 Aug 1;13(8):2796-807. doi: 10.1021/acs.molpharmaceut.6b00396. Epub 2016 Jul 14. Mol Pharm. 2016. PMID: 27377099

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