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Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex.
Chiba S, Numakawa T, Ninomiya M, Richards MC, Wakabayashi C, Kunugi H. Chiba S, et al. Among authors: numakawa t. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):112-9. doi: 10.1016/j.pnpbp.2012.05.018. Epub 2012 Jun 1. Prog Neuropsychopharmacol Biol Psychiatry. 2012. PMID: 22664354
Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release.
Yagasaki Y, Numakawa T, Kumamaru E, Hayashi T, Su TP, Kunugi H. Yagasaki Y, et al. Among authors: numakawa t. J Biol Chem. 2006 May 5;281(18):12941-9. doi: 10.1074/jbc.M508157200. Epub 2006 Mar 6. J Biol Chem. 2006. PMID: 16522641 Free article.
Because BDNF has been shown by us to reinforce excitatory glutamatergic transmission in cultured cortical neurons via the phospholipase-gamma (PLC-gamma)/inositol 1,4,5-trisphosphate (IP3)/Ca2+ pathway (Numakawa, T., Yamagishi, S., Adachi, N., Matsumoto, T., …
Because BDNF has been shown by us to reinforce excitatory glutamatergic transmission in cultured cortical neurons via the phospholipase-gamm …
Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling.
Hashimoto R, Numakawa T, Ohnishi T, Kumamaru E, Yagasaki Y, Ishimoto T, Mori T, Nemoto K, Adachi N, Izumi A, Chiba S, Noguchi H, Suzuki T, Iwata N, Ozaki N, Taguchi T, Kamiya A, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Sawa A, Kunugi H. Hashimoto R, et al. Among authors: numakawa t. Hum Mol Genet. 2006 Oct 15;15(20):3024-33. doi: 10.1093/hmg/ddl244. Epub 2006 Sep 7. Hum Mol Genet. 2006. PMID: 16959794
88 results