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Identification of novel drug-resistant EGFR mutant inhibitors by in silico screening using comprehensive assessments of protein structures.
Sato T, Watanabe H, Tsuganezawa K, Yuki H, Mikuni J, Yoshikawa S, Kukimoto-Niino M, Fujimoto T, Terazawa Y, Wakiyama M, Kojima H, Okabe T, Nagano T, Shirouzu M, Yokoyama S, Tanaka A, Honma T. Sato T, et al. Among authors: shirouzu m. Bioorg Med Chem. 2012 Jun 15;20(12):3756-67. doi: 10.1016/j.bmc.2012.04.042. Epub 2012 Apr 27. Bioorg Med Chem. 2012. PMID: 22607878
Upstream mechanisms of glycogen synthase activation by insulin and insulin-like growth factor-I. Glycogen synthase activation is antagonized by wortmannin or LY294002 but not by rapamycin or by inhibiting p21ras.
Yamamoto-Honda R, Tobe K, Kaburagi Y, Ueki K, Asai S, Yachi M, Shirouzu M, Yodoi J, Akanuma Y, Yokoyama S, et al. Yamamoto-Honda R, et al. Among authors: shirouzu m. J Biol Chem. 1995 Feb 10;270(6):2729-34. doi: 10.1074/jbc.270.6.2729. J Biol Chem. 1995. PMID: 7852343 Free article.
A constitutive effector region on the C-terminal side of switch I of the Ras protein.
Fujita-Yoshigaki J, Shirouzu M, Ito Y, Hattori S, Furuyama S, Nishimura S, Yokoyama S. Fujita-Yoshigaki J, et al. Among authors: shirouzu m. J Biol Chem. 1995 Mar 3;270(9):4661-7. doi: 10.1074/jbc.270.9.4661. J Biol Chem. 1995. PMID: 7876237 Free article.
As for a region on the C-terminal side of switch I, the V45E and G48C mutants of Ras failed to promote neurite outgrowth of PC12 cells (Fujita-Yoshigaki, J., Shirouzu, M., Koide, H., Nishimura, S., and Yokoyama, S. (1991) FEBS Lett. 294, 187-190). ...Therefore, the …
As for a region on the C-terminal side of switch I, the V45E and G48C mutants of Ras failed to promote neurite outgrowth of PC12 cells (Fuji …
432 results