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Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy.
Bierhaus A, Fleming T, Stoyanov S, Leffler A, Babes A, Neacsu C, Sauer SK, Eberhardt M, Schnölzer M, Lasitschka F, Neuhuber WL, Kichko TI, Konrade I, Elvert R, Mier W, Pirags V, Lukic IK, Morcos M, Dehmer T, Rabbani N, Thornalley PJ, Edelstein D, Nau C, Forbes J, Humpert PM, Schwaninger M, Ziegler D, Stern DM, Cooper ME, Haberkorn U, Brownlee M, Reeh PW, Nawroth PP. Bierhaus A, et al. Among authors: morcos m. Nat Med. 2012 Jun;18(6):926-33. doi: 10.1038/nm.2750. Nat Med. 2012. PMID: 22581285
Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB.
Hofmann MA, Schiekofer S, Isermann B, Kanitz M, Henkels M, Joswig M, Treusch A, Morcos M, Weiss T, Borcea V, Abdel Khalek AK, Amiral J, Tritschler H, Ritz E, Wahl P, Ziegler R, Bierhaus A, Nawroth PP. Hofmann MA, et al. Among authors: morcos m. Diabetologia. 1999 Feb;42(2):222-32. doi: 10.1007/s001250051142. Diabetologia. 1999. PMID: 10064103
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB.
Bierhaus A, Schiekofer S, Schwaninger M, Andrassy M, Humpert PM, Chen J, Hong M, Luther T, Henle T, Klöting I, Morcos M, Hofmann M, Tritschler H, Weigle B, Kasper M, Smith M, Perry G, Schmidt AM, Stern DM, Häring HU, Schleicher E, Nawroth PP. Bierhaus A, et al. Among authors: morcos m. Diabetes. 2001 Dec;50(12):2792-808. doi: 10.2337/diabetes.50.12.2792. Diabetes. 2001. PMID: 11723063
Activation of tubular epithelial cells in diabetic nephropathy.
Morcos M, Sayed AA, Bierhaus A, Yard B, Waldherr R, Merz W, Kloeting I, Schleicher E, Mentz S, Abd el Baki RF, Tritschler H, Kasper M, Schwenger V, Hamann A, Dugi KA, Schmidt AM, Stern D, Ziegler R, Haering HU, Andrassy M, van der Woude F, Nawroth PP. Morcos M, et al. Diabetes. 2002 Dec;51(12):3532-44. doi: 10.2337/diabetes.51.12.3532. Diabetes. 2002. PMID: 12453911
A mechanism converting psychosocial stress into mononuclear cell activation.
Bierhaus A, Wolf J, Andrassy M, Rohleder N, Humpert PM, Petrov D, Ferstl R, von Eynatten M, Wendt T, Rudofsky G, Joswig M, Morcos M, Schwaninger M, McEwen B, Kirschbaum C, Nawroth PP. Bierhaus A, et al. Among authors: morcos m. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1920-5. doi: 10.1073/pnas.0438019100. Epub 2003 Feb 10. Proc Natl Acad Sci U S A. 2003. PMID: 12578963 Free PMC article.
A 63bp deletion in the promoter of rage correlates with a decreased risk for nephropathy in patients with type 2 diabetes.
Rudofsky G Jr, Isermann B, Schilling T, Schiekofer S, Andrassy M, Schneider JG, Morcos M, Humpert PM, Sayed AA, Witte S, Renn W, Pfohl M, Hamann A, Nosikov V, Schleicher E, Häring HU, Rudofsky G, Ritz E, Nawroth PP, Bierhaus A. Rudofsky G Jr, et al. Among authors: morcos m. Exp Clin Endocrinol Diabetes. 2004 Mar;112(3):135-41. doi: 10.1055/s-2004-817822. Exp Clin Endocrinol Diabetes. 2004. PMID: 15052533
215 results