Harrenga A - Search Results

1

Discovery of substituted N-phenylbenzenesulphonamides as a novel class of non-nucleoside hepatitis C virus polymerase inhibitors.

May MM, Brohm D, Harrenga A, Marquardt T, Riedl B, Kreuter J, Zimmermann H, Ruebsamen-Schaeff H, Urban A. May MM, et al. Among authors: harrenga a. Antiviral Res. 2012 Aug;95(2):182-91. doi: 10.1016/j.antiviral.2012.04.008. Epub 2012 May 10. Antiviral Res. 2012. PMID: 22580131

2

Unexpected active-site flexibility in the structure of human neutrophil elastase in complex with a new dihydropyrimidone inhibitor.

Hansen G, Gielen-Haertwig H, Reinemer P, Schomburg D, Harrenga A, Niefind K. Hansen G, et al. Among authors: harrenga a. J Mol Biol. 2011 Jun 24;409(5):681-91. doi: 10.1016/j.jmb.2011.04.047. Epub 2011 Apr 27. J Mol Biol. 2011. PMID: 21549129

3

Crystal structure of full length topoisomerase I from Thermotoga maritima.

Hansen G, Harrenga A, Wieland B, Schomburg D, Reinemer P. Hansen G, et al. Among authors: harrenga a. J Mol Biol. 2006 May 19;358(5):1328-40. doi: 10.1016/j.jmb.2006.03.012. Epub 2006 Mar 23. J Mol Biol. 2006. PMID: 16600296

4

Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model.

von Nussbaum F, Li VM, Meibom D, Anlauf S, Bechem M, Delbeck M, Gerisch M, Harrenga A, Karthaus D, Lang D, Lustig K, Mittendorf J, Schäfer M, Schäfer S, Schamberger J. von Nussbaum F, et al. Among authors: harrenga a. ChemMedChem. 2016 Jan 19;11(2):199-206. doi: 10.1002/cmdc.201500269. Epub 2015 Sep 3. ChemMedChem. 2016. PMID: 26333652

5

Structure of the soluble domain of cytochrome c(552) from Paracoccus denitrificans in the oxidized and reduced states.

Harrenga A, Reincke B, Rüterjans H, Ludwig B, Michel H. Harrenga A, et al. J Mol Biol. 2000 Jan 21;295(3):667-78. doi: 10.1006/jmbi.1999.3382. J Mol Biol. 2000. PMID: 10623555

6

Preclinical Efficacy of the Auristatin-Based Antibody-Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors.

Sommer A, Kopitz C, Schatz CA, Nising CF, Mahlert C, Lerchen HG, Stelte-Ludwig B, Hammer S, Greven S, Schuhmacher J, Braun M, Zierz R, Wittemer-Rump S, Harrenga A, Dittmer F, Reetz F, Apeler H, Jautelat R, Huynh H, Ziegelbauer K, Kreft B. Sommer A, et al. Among authors: harrenga a. Cancer Res. 2016 Nov 1;76(21):6331-6339. doi: 10.1158/0008-5472.CAN-16-0180. Epub 2016 Aug 19. Cancer Res. 2016. PMID: 27543601

7

Structure at 2.7 A resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody FV fragment.

Ostermeier C, Harrenga A, Ermler U, Michel H. Ostermeier C, et al. Among authors: harrenga a. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10547-53. doi: 10.1073/pnas.94.20.10547. Proc Natl Acad Sci U S A. 1997. PMID: 9380672 Free PMC article.

8

Mutations in the Ca2+ binding site of the Paracoccus denitrificans cytochrome c oxidase.

Pfitzner U, Kirichenko A, Konstantinov AA, Mertens M, Wittershagen A, Kolbesen BO, Steffens GC, Harrenga A, Michel H, Ludwig B. Pfitzner U, et al. Among authors: harrenga a. FEBS Lett. 1999 Aug 13;456(3):365-9. doi: 10.1016/s0014-5793(99)00977-1. FEBS Lett. 1999. PMID: 10462045 Free article.

9

The cytochrome c oxidase from Paracoccus denitrificans does not change the metal center ligation upon reduction.

Harrenga A, Michel H. Harrenga A, et al. J Biol Chem. 1999 Nov 19;274(47):33296-9. doi: 10.1074/jbc.274.47.33296. J Biol Chem. 1999. PMID: 10559205 Free article.

10

Tracing the D-pathway in reconstituted site-directed mutants of cytochrome c oxidase from Paracoccus denitrificans.

Pfitzner U, Hoffmeier K, Harrenga A, Kannt A, Michel H, Bamberg E, Richter OM, Ludwig B. Pfitzner U, et al. Among authors: harrenga a. Biochemistry. 2000 Jun 13;39(23):6756-62. doi: 10.1021/bi992235x. Biochemistry. 2000. PMID: 10841754

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