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Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers.
Parikh C, Janakiraman V, Wu WI, Foo CK, Kljavin NM, Chaudhuri S, Stawiski E, Lee B, Lin J, Li H, Lorenzo MN, Yuan W, Guillory J, Jackson M, Rondon J, Franke Y, Bowman KK, Sagolla M, Stinson J, Wu TD, Wu J, Stokoe D, Stern HM, Brandhuber BJ, Lin K, Skelton NJ, Seshagiri S. Parikh C, et al. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19368-73. doi: 10.1073/pnas.1204384109. Epub 2012 Nov 7. Proc Natl Acad Sci U S A. 2012. PMID: 23134728 Free PMC article.
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents.
Degtyarev M, De Mazière A, Orr C, Lin J, Lee BB, Tien JY, Prior WW, van Dijk S, Wu H, Gray DC, Davis DP, Stern HM, Murray LJ, Hoeflich KP, Klumperman J, Friedman LS, Lin K. Degtyarev M, et al. Among authors: lee bb. J Cell Biol. 2008 Oct 6;183(1):101-16. doi: 10.1083/jcb.200801099. J Cell Biol. 2008. PMID: 18838554 Free PMC article.
Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors.
Blake JF, Xu R, Bencsik JR, Xiao D, Kallan NC, Schlachter S, Mitchell IS, Spencer KL, Banka AL, Wallace EM, Gloor SL, Martinson M, Woessner RD, Vigers GP, Brandhuber BJ, Liang J, Safina BS, Li J, Zhang B, Chabot C, Do S, Lee L, Oeh J, Sampath D, Lee BB, Lin K, Liederer BM, Skelton NJ. Blake JF, et al. Among authors: lee l, lee bb. J Med Chem. 2012 Sep 27;55(18):8110-27. doi: 10.1021/jm301024w. Epub 2012 Sep 18. J Med Chem. 2012. PMID: 22934575
Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models.
Lin J, Sampath D, Nannini MA, Lee BB, Degtyarev M, Oeh J, Savage H, Guan Z, Hong R, Kassees R, Lee LB, Risom T, Gross S, Liederer BM, Koeppen H, Skelton NJ, Wallin JJ, Belvin M, Punnoose E, Friedman LS, Lin K. Lin J, et al. Among authors: lee lb, lee bb. Clin Cancer Res. 2013 Apr 1;19(7):1760-72. doi: 10.1158/1078-0432.CCR-12-3072. Epub 2013 Jan 3. Clin Cancer Res. 2013. PMID: 23287563
Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors.
Savill KMZ, Lee BB, Oeh J, Lin J, Lin E, Chung WJ, Young A, Chen W, Miś M, Mesh K, Eastham J, Gnad F, Jiang Z, Stawiski EW, Haley B, Daemen A, Wang X, Koeppen H, Modrusan Z, Martin SE, Sampath D, Lin K. Savill KMZ, et al. Among authors: lee bb. Nat Commun. 2022 Apr 19;13(1):2057. doi: 10.1038/s41467-022-29655-0. Nat Commun. 2022. PMID: 35440108 Free PMC article.
Increases in nuclear p65 activation in dystrophic skeletal muscle are secondary to increases in the cellular expression of p65 and are not solely produced by increases in IkappaB-alpha kinase activity.
Singh R, Millman G, Turin E, Polisiakeiwicz L, Lee B, Gatti F, Berge J, Smith E, Rutter J, Sumski C, Winders WT, Samadi A, Carlson CG. Singh R, et al. J Neurol Sci. 2009 Oct 15;285(1-2):159-71. doi: 10.1016/j.jns.2009.06.030. Epub 2009 Jul 24. J Neurol Sci. 2009. PMID: 19631348
Fake-news-free evidence-based communication for proper vein-lymphatic disease management.
Gianesini S, Chi YW, Agüero C, Alqedrah D, Amore M, Barbati M, Baturone A, Black S, Borsuk D, Bottini O, Caprini J, Chamo M, Cherian M, Chernuka L, DE Maeseneer M, Diaz J, Garcia MJ, Gibson K, Gloviczki M, Gloviczki P, Golovina V, Goranova E, Grillo L, Gwozdz A, Hirsch T, Hussein E, Intriago E, Jalaie H, Jaworucka-Kaczorowska A, Jindal R, Josnin M, Khilnani NM, Kim DI, Latorre A, Lazarashvili Z, Lee BB, Leon L, Liew NC, Lobastov K, Lurie F, Maghetti A, Menegatti E, Miyake K, Mo M, Narayanan S, Neuhardt D, Pannier F, Prego A, Rabe E, Raffetto J, Raymond-Martimbeau P, Redman L, Reina-Gutierrez L, Rial R, Rockson S, Romanelli M, Santiago FR, Santiago RA, Sermsathanasawadi N, Shaydakov E, Simkin C, Sousa J, Stoughton J, Szuba A, Taha W, Ulloa J, Urbanek T, Vitale M, Vuylsteke M, Wang J, Weingartner J, Wilson S, Yamaki T, Ng Y, Zolotukhin I, Mansilha A. Gianesini S, et al. Among authors: lee bb. Int Angiol. 2023 Apr;42(2):89-189. doi: 10.23736/S0392-9590.23.05044-7. Epub 2023 Mar 17. Int Angiol. 2023. PMID: 36930179 Free article.
397 results