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N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase.
Yin Z, Chen YL, Kondreddi RR, Chan WL, Wang G, Ng RH, Lim JY, Lee WY, Jeyaraj DA, Niyomrattanakit P, Wen D, Chao A, Glickman JF, Voshol H, Mueller D, Spanka C, Dressler S, Nilar S, Vasudevan SG, Shi PY, Keller TH. Yin Z, et al. Among authors: nilar s. J Med Chem. 2009 Dec 24;52(24):7934-7. doi: 10.1021/jm901044z. J Med Chem. 2009. PMID: 20014868
Lead optimization of spiropyrazolopyridones: a new and potent class of dengue virus inhibitors.
Zou B, Chan WL, Ding M, Leong SY, Nilar S, Seah PG, Liu W, Karuna R, Blasco F, Yip A, Chao A, Susila A, Dong H, Wang QY, Xu HY, Chan K, Wan KF, Gu F, Diagana TT, Wagner T, Dix I, Shi PY, Smith PW. Zou B, et al. Among authors: nilar s. ACS Med Chem Lett. 2015 Feb 2;6(3):344-8. doi: 10.1021/ml500521r. eCollection 2015 Mar 12. ACS Med Chem Lett. 2015. PMID: 25878766 Free PMC article.
Small molecule inhibitors that selectively block dengue virus methyltransferase.
Lim SP, Sonntag LS, Noble C, Nilar SH, Ng RH, Zou G, Monaghan P, Chung KY, Dong H, Liu B, Bodenreider C, Lee G, Ding M, Chan WL, Wang G, Jian YL, Chao AT, Lescar J, Yin Z, Vedananda TR, Keller TH, Shi PY. Lim SP, et al. J Biol Chem. 2011 Feb 25;286(8):6233-40. doi: 10.1074/jbc.M110.179184. Epub 2010 Dec 8. J Biol Chem. 2011. PMID: 21147775 Free PMC article.
Inhibition of dengue virus polymerase by blocking of the RNA tunnel.
Niyomrattanakit P, Chen YL, Dong H, Yin Z, Qing M, Glickman JF, Lin K, Mueller D, Voshol H, Lim JY, Nilar S, Keller TH, Shi PY. Niyomrattanakit P, et al. Among authors: nilar s. J Virol. 2010 Jun;84(11):5678-86. doi: 10.1128/JVI.02451-09. Epub 2010 Mar 17. J Virol. 2010. PMID: 20237086 Free PMC article.
Inhibition of dengue virus through suppression of host pyrimidine biosynthesis.
Wang QY, Bushell S, Qing M, Xu HY, Bonavia A, Nunes S, Zhou J, Poh MK, Florez de Sessions P, Niyomrattanakit P, Dong H, Hoffmaster K, Goh A, Nilar S, Schul W, Jones S, Kramer L, Compton T, Shi PY. Wang QY, et al. Among authors: nilar s. J Virol. 2011 Jul;85(13):6548-56. doi: 10.1128/JVI.02510-10. Epub 2011 Apr 20. J Virol. 2011. PMID: 21507975 Free PMC article.
23 results