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The isoprenoid-precursor dependence of Plasmodium spp.
van der Meer JY, Hirsch AK. van der Meer JY, et al. Among authors: hirsch ak. Nat Prod Rep. 2012 Jul;29(7):721-8. doi: 10.1039/c2np20013a. Epub 2012 May 4. Nat Prod Rep. 2012. PMID: 22555616 Review.
Druggability of the enzymes of the non-mevalonate-pathway.
Masini T, Kroezen BS, Hirsch AK. Masini T, et al. Among authors: hirsch ak. Drug Discov Today. 2013 Dec;18(23-24):1256-62. doi: 10.1016/j.drudis.2013.07.003. Epub 2013 Jul 13. Drug Discov Today. 2013. PMID: 23856326 Review.
DXS as a target for structure-based drug design.
Gierse RM, Redeem E, Diamanti E, Wrenger C, Groves MR, Hirsch AK. Gierse RM, et al. Among authors: hirsch ak. Future Med Chem. 2017 Jul;9(11):1277-1294. doi: 10.4155/fmc-2016-0239. Epub 2017 Jun 21. Future Med Chem. 2017. PMID: 28636418 Review.
Optimized Inhibitors of MDM2 via an Attempted Protein-Templated Reductive Amination.
van der Vlag R, Yagiz Unver M, Felicetti T, Twarda-Clapa A, Kassim F, Ermis C, Neochoritis CG, Musielak B, Labuzek B, Dömling A, Holak TA, Hirsch AKH. van der Vlag R, et al. ChemMedChem. 2020 Feb 17;15(4):370-375. doi: 10.1002/cmdc.201900574. Epub 2019 Dec 12. ChemMedChem. 2020. PMID: 31774938 Free PMC article.
Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach.
Konstantinidou M, Magari F, Sutanto F, Haupenthal J, Jumde VR, Ünver MY, Heine A, Camacho CJ, Hirsch AKH, Klebe G, Dömling A. Konstantinidou M, et al. ChemMedChem. 2020 Apr 20;15(8):680-684. doi: 10.1002/cmdc.202000024. Epub 2020 Mar 18. ChemMedChem. 2020. PMID: 32187447 Free PMC article.
High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum.
Johannsen S, Gierse RM, Krüger A, Edwards RL, Nanna V, Fontana A, Zhu D, Masini T, de Carvalho LP, Poizat M, Kieftenbelt B, Hodge DM, Alvarez S, Bunt D, Lacour A, Shams A, Meissner KA, de Souza EE, Dröge M, van Vliet B, den Hartog J, Hutter MC, Held J, Odom John AR, Wrenger C, Hirsch AKH. Johannsen S, et al. Among authors: hirsch akh. ACS Infect Dis. 2024 Mar 8;10(3):1000-1022. doi: 10.1021/acsinfecdis.3c00670. Epub 2024 Feb 17. ACS Infect Dis. 2024. PMID: 38367280 Free PMC article.
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