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The tumor necrosis factor receptor stalk regions define responsiveness to soluble versus membrane-bound ligand.
Mol Cell Biol. 2012 Jul;32(13):2515-29. doi: 10.1128/MCB.06458-11. Epub 2012 Apr 30.
Mol Cell Biol. 2012.
PMID: 22547679
Free PMC article.
Dual function of cysteine rich domain (CRD) 1 of TNF receptor type 1: conformational stabilization of CRD2 and control of receptor responsiveness.
Branschädel M, Aird A, Zappe A, Tietz C, Krippner-Heidenreich A, Scheurich P.
Branschädel M, et al.
Cell Signal. 2010 Mar;22(3):404-14. doi: 10.1016/j.cellsig.2009.10.011.
Cell Signal. 2010.
PMID: 19879354
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Single chain TNF derivatives with individually mutated receptor binding sites reveal differential stoichiometry of ligand receptor complex formation for TNFR1 and TNFR2.
Boschert V, Krippner-Heidenreich A, Branschädel M, Tepperink J, Aird A, Scheurich P.
Boschert V, et al. Among authors: branschadel m.
Cell Signal. 2010 Jul;22(7):1088-96. doi: 10.1016/j.cellsig.2010.02.011. Epub 2010 Mar 4.
Cell Signal. 2010.
PMID: 20206684
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The transmembrane domains of TNF-related apoptosis-inducing ligand (TRAIL) receptors 1 and 2 co-regulate apoptotic signaling capacity.
Neumann S, Bidon T, Branschädel M, Krippner-Heidenreich A, Scheurich P, Doszczak M.
Neumann S, et al. Among authors: branschadel m.
PLoS One. 2012;7(8):e42526. doi: 10.1371/journal.pone.0042526. Epub 2012 Aug 3.
PLoS One. 2012.
PMID: 22916132
Free PMC article.
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A humanized tumor necrosis factor receptor 1 (TNFR1)-specific antagonistic antibody for selective inhibition of tumor necrosis factor (TNF) action.
Kontermann RE, Münkel S, Neumeyer J, Müller D, Branschädel M, Scheurich P, Pfizenmaier K.
Kontermann RE, et al. Among authors: branschadel m.
J Immunother. 2008 Apr;31(3):225-34. doi: 10.1097/CJI.0b013e31816a88f9.
J Immunother. 2008.
PMID: 18317365
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APG350 induces superior clustering of TRAIL receptors and shows therapeutic antitumor efficacy independent of cross-linking via Fcγ receptors.
Gieffers C, Kluge M, Merz C, Sykora J, Thiemann M, Schaal R, Fischer C, Branschädel M, Abhari BA, Hohenberger P, Fulda S, Fricke H, Hill O.
Gieffers C, et al. Among authors: branschadel m.
Mol Cancer Ther. 2013 Dec;12(12):2735-47. doi: 10.1158/1535-7163.MCT-13-0323. Epub 2013 Oct 7.
Mol Cancer Ther. 2013.
PMID: 24101228
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