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Page 1
Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors.
Escribano A, Mateo AI, Martin de la Nava EM, Mayhugh DR, Cockerham SL, Beyer TP, Schmidt RJ, Cao G, Zhang Y, Jones TM, Borel AG, Sweetana SA, Cannady EA, Mantlo NB. Escribano A, et al. Among authors: cockerham sl. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3671-5. doi: 10.1016/j.bmcl.2012.04.042. Epub 2012 Apr 13. Bioorg Med Chem Lett. 2012. PMID: 22543028
Design, synthesis and structure-activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors.
Fernandez MC, Escribano A, Mateo AI, Parthasarathy S, Martin de la Nava EM, Wang X, Cockerham SL, Beyer TP, Schmidt RJ, Cao G, Zhang Y, Jones TM, Borel A, Sweetana SA, Cannady EA, Stephenson G, Frank S, Mantlo NB. Fernandez MC, et al. Among authors: cockerham sl. Bioorg Med Chem Lett. 2012 May 1;22(9):3056-62. doi: 10.1016/j.bmcl.2012.03.075. Epub 2012 Mar 28. Bioorg Med Chem Lett. 2012. PMID: 22497761
Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure.
Cao G, Beyer TP, Zhang Y, Schmidt RJ, Chen YQ, Cockerham SL, Zimmerman KM, Karathanasis SK, Cannady EA, Fields T, Mantlo NB. Cao G, et al. Among authors: cockerham sl. J Lipid Res. 2011 Dec;52(12):2169-2176. doi: 10.1194/jlr.M018069. Epub 2011 Sep 25. J Lipid Res. 2011. PMID: 21957197 Free PMC article.
Synthetic and structure/activity studies on acid-substituted 2-arylphenols: discovery of 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy]-propoxy]phenoxy]benzoic acid, a high-affinity leukotriene B4 receptor antagonist.
Sawyer JS, Bach NJ, Baker SR, Baldwin RF, Borromeo PS, Cockerham SL, Fleisch JH, Floreancig P, Froelich LL, Jackson WT, et al. Sawyer JS, et al. Among authors: cockerham sl. J Med Chem. 1995 Oct 27;38(22):4411-32. doi: 10.1021/jm00022a006. J Med Chem. 1995. PMID: 7473568
o-phenylphenols: potent and orally active leukotriene B4 receptor antagonists.
Sofia MJ, Floreancig P, Bach NJ, Baker SR, Cockerham SL, Fleisch JH, Froelich LL, Jackson WT, Marder P, Roman CR, et al. Sofia MJ, et al. Among authors: cockerham sl. J Med Chem. 1993 Nov 26;36(24):3978-81. doi: 10.1021/jm00076a029. J Med Chem. 1993. PMID: 7902871 No abstract available.
Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist.
Silbaugh SA, Stengel PW, Cockerham SL, Roman CR, Saussy DL Jr, Spaethe SM, Goodson T Jr, Herron DK, Fleisch JH. Silbaugh SA, et al. Among authors: cockerham sl. Eur J Pharmacol. 1992 Nov 13;223(1):57-64. doi: 10.1016/0014-2999(92)90818-o. Eur J Pharmacol. 1992. PMID: 1335877
Aerosolized LTB4 produces delayed onset increases in pulmonary gas trapping.
Silbaugh SA, Stengel PW, Cockerham SL, Froelich LL, Bendele AM, Rippy MK, Baker SR, Sofia MJ, Jackson WT. Silbaugh SA, et al. Among authors: cockerham sl. Prostaglandins Leukot Essent Fatty Acids. 1996 Feb;54(2):115-21. doi: 10.1016/s0952-3278(96)90068-x. Prostaglandins Leukot Essent Fatty Acids. 1996. PMID: 8848430
The discovery of LY293111, a novel, potent and orally active leukotriene B4 receptor antagonist of the biphenylphenol class.
Sofia MJ, Floreancig P, Bach N, Baker SR, Nelson K, Sawyer JS, Baldwin R, Cockerham SL, Fleisch JH, Froelich LL, Jackson WT, Marder P, Roman CR, Saussy DL Jr, Silbaugh SA, Spaethe SM, Stengel PW. Sofia MJ, et al. Among authors: cockerham sl. Adv Exp Med Biol. 1997;400A:381-6. doi: 10.1007/978-1-4615-5325-0_51. Adv Exp Med Biol. 1997. PMID: 9547580 No abstract available.
21 results