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A new class of highly potent matrix metalloproteinase inhibitors based on triazole-substituted hydroxamates: (radio)synthesis and in vitro and first in vivo evaluation.
Hugenberg V, Breyholz HJ, Riemann B, Hermann S, Schober O, Schäfers M, Gangadharmath U, Mocharla V, Kolb H, Walsh J, Zhang W, Kopka K, Wagner S. Hugenberg V, et al. Among authors: mocharla v. J Med Chem. 2012 May 24;55(10):4714-27. doi: 10.1021/jm300199g. Epub 2012 May 16. J Med Chem. 2012. PMID: 22540974
Radiolabeled hydroxamate-based matrix metalloproteinase inhibitors: How chemical modifications affect pharmacokinetics and metabolic stability.
Hugenberg V, Hermann S, Galla F, Schäfers M, Wünsch B, Kolb HC, Szardenings K, Lebedev A, Walsh JC, Mocharla VP, Gangadharmath UB, Kopka K, Wagner S. Hugenberg V, et al. Among authors: mocharla vp. Nucl Med Biol. 2016 Jul;43(7):424-37. doi: 10.1016/j.nucmedbio.2016.03.005. Epub 2016 Mar 17. Nucl Med Biol. 2016. PMID: 27179748
A highly selective and specific PET tracer for imaging of tau pathologies.
Zhang W, Arteaga J, Cashion DK, Chen G, Gangadharmath U, Gomez LF, Kasi D, Lam C, Liang Q, Liu C, Mocharla VP, Mu F, Sinha A, Szardenings AK, Wang E, Walsh JC, Xia C, Yu C, Zhao T, Kolb HC. Zhang W, et al. Among authors: mocharla vp. J Alzheimers Dis. 2012;31(3):601-12. doi: 10.3233/JAD-2012-120712. J Alzheimers Dis. 2012. PMID: 22683529
[(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease.
Xia CF, Arteaga J, Chen G, Gangadharmath U, Gomez LF, Kasi D, Lam C, Liang Q, Liu C, Mocharla VP, Mu F, Sinha A, Su H, Szardenings AK, Walsh JC, Wang E, Yu C, Zhang W, Zhao T, Kolb HC. Xia CF, et al. Among authors: mocharla vp. Alzheimers Dement. 2013 Nov;9(6):666-76. doi: 10.1016/j.jalz.2012.11.008. Epub 2013 Feb 12. Alzheimers Dement. 2013. PMID: 23411393
Evaluation of [(18)F]-CP18 as a PET imaging tracer for apoptosis.
Su H, Chen G, Gangadharmath U, Gomez LF, Liang Q, Mu F, Mocharla VP, Szardenings AK, Walsh JC, Xia CF, Yu C, Kolb HC. Su H, et al. Among authors: mocharla vp. Mol Imaging Biol. 2013 Dec;15(6):739-47. doi: 10.1007/s11307-013-0644-9. Mol Imaging Biol. 2013. PMID: 23681757
15 results