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An inhibitor of neuronal exocytosis (DD04107) displays long-lasting in vivo activity against chronic inflammatory and neuropathic pain.
Ponsati B, Carreño C, Curto-Reyes V, Valenzuela B, Duart MJ, Van den Nest W, Cauli O, Beltran B, Fernandez J, Borsini F, Caprioli A, Di Serio S, Veretchy M, Baamonde A, Menendez L, Barros F, de la Pena P, Borges R, Felipo V, Planells-Cases R, Ferrer-Montiel A. Ponsati B, et al. Among authors: van den nest w. J Pharmacol Exp Ther. 2012 Jun;341(3):634-45. doi: 10.1124/jpet.111.190678. Epub 2012 Mar 5. J Pharmacol Exp Ther. 2012. PMID: 22393248 Free article.
Design and characterization of a noncompetitive antagonist of the transient receptor potential vanilloid subunit 1 channel with in vivo analgesic and anti-inflammatory activity.
García-Martínez C, Fernández-Carvajal A, Valenzuela B, Gomis A, Van Den Nest W, Ferroni S, Carreño C, Belmonte C, Ferrer-Montiel A. García-Martínez C, et al. Among authors: van den nest w. J Pain. 2006 Oct;7(10):735-46. doi: 10.1016/j.jpain.2006.03.008. J Pain. 2006. PMID: 17018334 Free article.
Conformational restriction of the Tyr53 side-chain in the decapeptide HE.
Casimir JR, Iterbeke K, Van Den Nest W, Trescol-Biémont MC, Dumortier H, Muller S, Gerlier D, Rabourdin-Combe C, Tourwé D, Paris J. Casimir JR, et al. Among authors: van den nest w. J Pept Res. 2000 Dec;56(6):398-408. doi: 10.1034/j.1399-3011.2000.00777.x. J Pept Res. 2000. PMID: 11152299