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An inhibitor of neuronal exocytosis (DD04107) displays long-lasting in vivo activity against chronic inflammatory and neuropathic pain.
Ponsati B, Carreño C, Curto-Reyes V, Valenzuela B, Duart MJ, Van den Nest W, Cauli O, Beltran B, Fernandez J, Borsini F, Caprioli A, Di Serio S, Veretchy M, Baamonde A, Menendez L, Barros F, de la Pena P, Borges R, Felipo V, Planells-Cases R, Ferrer-Montiel A. Ponsati B, et al. Among authors: borsini f. J Pharmacol Exp Ther. 2012 Jun;341(3):634-45. doi: 10.1124/jpet.111.190678. Epub 2012 Mar 5. J Pharmacol Exp Ther. 2012. PMID: 22393248 Free article.
The novel reversible fatty acid amide hydrolase inhibitor ST4070 increases endocannabinoid brain levels and counteracts neuropathic pain in different animal models.
Caprioli A, Coccurello R, Rapino C, Di Serio S, Di Tommaso M, Vertechy M, Vacca V, Battista N, Pavone F, Maccarrone M, Borsini F. Caprioli A, et al. Among authors: borsini f. J Pharmacol Exp Ther. 2012 Jul;342(1):188-95. doi: 10.1124/jpet.111.191403. Epub 2012 Apr 18. J Pharmacol Exp Ther. 2012. PMID: 22514334
Animal models of Parkinson׳s disease: Effects of two adenosine A2A receptor antagonists ST4206 and ST3932, metabolites of 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535).
Stasi MA, Minetti P, Lombardo K, Riccioni T, Caprioli A, Vertechy M, Di Serio S, Pace S, Borsini F. Stasi MA, et al. Among authors: borsini f. Eur J Pharmacol. 2015 Aug 15;761:353-61. doi: 10.1016/j.ejphar.2015.03.070. Epub 2015 Apr 30. Eur J Pharmacol. 2015. PMID: 25936513
Olanzapine (LY170053, 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine), but not the novel atypical antipsychotic ST2472 (9-piperazin-1-ylpyrrolo[2,1-b][1,3]benzothiazepine), chronic administration induces weight gain, hyperphagia, and metabolic dysregulation in mice.
Coccurello R, Caprioli A, Conti R, Ghirardi O, Borsini F, Carminati P, Moles A. Coccurello R, et al. Among authors: borsini f. J Pharmacol Exp Ther. 2008 Sep;326(3):905-11. doi: 10.1124/jpet.108.137240. Epub 2008 Jun 20. J Pharmacol Exp Ther. 2008. PMID: 18567835
Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.
Butini S, Brindisi M, Gemma S, Minetti P, Cabri W, Gallo G, Vincenti S, Talamonti E, Borsini F, Caprioli A, Stasi MA, Di Serio S, Ros S, Borrelli G, Maramai S, Fezza F, Campiani G, Maccarrone M. Butini S, et al. Among authors: borsini f. J Med Chem. 2012 Aug 9;55(15):6898-915. doi: 10.1021/jm300689c. Epub 2012 Jul 26. J Med Chem. 2012. PMID: 22779702
ST2472: a new potential antipsychotic with very low liability to induce side-effects.
Stasi MA, Di Serio S, Vertechy M, Schiavone A, Ghirardi O, Minetti P, Campiani G, Borsini F, Carminati P. Stasi MA, et al. Among authors: borsini f. Int J Neuropsychopharmacol. 2008 May;11(3):309-19. doi: 10.1017/S146114570700805X. Epub 2007 Oct 10. Int J Neuropsychopharmacol. 2008. PMID: 17925059 Free article.
Enol carbamates as inhibitors of fatty acid amide hydrolase (FAAH) endowed with high selectivity for FAAH over the other targets of the endocannabinoid system.
Gattinoni S, De Simone C, Dallavalle S, Fezza F, Nannei R, Amadio D, Minetti P, Quattrociocchi G, Caprioli A, Borsini F, Cabri W, Penco S, Merlini L, Maccarrone M. Gattinoni S, et al. Among authors: borsini f. ChemMedChem. 2010 Mar 1;5(3):357-60. doi: 10.1002/cmdc.200900472. ChemMedChem. 2010. PMID: 20112328 No abstract available.
148 results