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Polyglutamine expansion in huntingtin alters its interaction with phospholipids.
Kegel KB, Sapp E, Alexander J, Valencia A, Reeves P, Li X, Masso N, Sobin L, Aronin N, DiFiglia M. Kegel KB, et al. Among authors: valencia a. J Neurochem. 2009 Sep;110(5):1585-97. doi: 10.1111/j.1471-4159.2009.06255.x. Epub 2009 Jun 29. J Neurochem. 2009. PMID: 19566678 Free article.
Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity.
Li X, Standley C, Sapp E, Valencia A, Qin ZH, Kegel KB, Yoder J, Comer-Tierney LA, Esteves M, Chase K, Alexander J, Masso N, Sobin L, Bellve K, Tuft R, Lifshitz L, Fogarty K, Aronin N, DiFiglia M. Li X, et al. Among authors: valencia a. Mol Cell Biol. 2009 Nov;29(22):6106-16. doi: 10.1128/MCB.00420-09. Epub 2009 Sep 14. Mol Cell Biol. 2009. PMID: 19752198 Free PMC article.
A function of huntingtin in guanine nucleotide exchange on Rab11.
Li X, Sapp E, Valencia A, Kegel KB, Qin ZH, Alexander J, Masso N, Reeves P, Ritch JJ, Zeitlin S, Aronin N, Difiglia M. Li X, et al. Among authors: valencia a. Neuroreport. 2008 Oct 29;19(16):1643-7. doi: 10.1097/WNR.0b013e328315cd4c. Neuroreport. 2008. PMID: 18845944
Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease.
Li X, Sapp E, Chase K, Comer-Tierney LA, Masso N, Alexander J, Reeves P, Kegel KB, Valencia A, Esteves M, Aronin N, Difiglia M. Li X, et al. Among authors: valencia a. Neurobiol Dis. 2009 Nov;36(2):374-83. doi: 10.1016/j.nbd.2009.08.003. Epub 2009 Aug 20. Neurobiol Dis. 2009. PMID: 19699304 Free PMC article.
Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors.
Kegel KB, Sapp E, Alexander J, Reeves P, Bleckmann D, Sobin L, Masso N, Valencia A, Jeong H, Krainc D, Palacino J, Curtis D, Kuhn R, Betschart C, Sena-Esteves M, Aronin N, Paganetti P, Difiglia M. Kegel KB, et al. Among authors: valencia a. Mol Neurodegener. 2010 Dec 14;5:58. doi: 10.1186/1750-1326-5-58. Mol Neurodegener. 2010. PMID: 21156064 Free PMC article.
935 results