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Elafibranor upregulates the EMT-inducer S100A4 via PPARβ/δ.
Zhang M, Barroso E, Ruart M, Peña L, Peyman M, Aguilar-Recarte D, Montori-Grau M, Rada P, Cugat C, Montironi C, Zarei M, Jurado-Aguilar J, Camins A, Balsinde J, Valverde ÁM, Wahli W, Palomer X, Vázquez-Carrera M. Zhang M, et al. Among authors: pena l. Biomed Pharmacother. 2023 Nov;167:115623. doi: 10.1016/j.biopha.2023.115623. Epub 2023 Sep 30. Biomed Pharmacother. 2023. PMID: 37783154 Free article.
GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK.
Aguilar-Recarte D, Barroso E, Gumà A, Pizarro-Delgado J, Peña L, Ruart M, Palomer X, Wahli W, Vázquez-Carrera M. Aguilar-Recarte D, et al. Among authors: pena l. Cell Rep. 2021 Aug 10;36(6):109501. doi: 10.1016/j.celrep.2021.109501. Cell Rep. 2021. PMID: 34380027 Free article.
PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders.
Palomer X, Barroso E, Pizarro-Delgado J, Peña L, Botteri G, Zarei M, Aguilar D, Montori-Grau M, Vázquez-Carrera M. Palomer X, et al. Among authors: pena l. Int J Mol Sci. 2018 Mar 20;19(3):913. doi: 10.3390/ijms19030913. Int J Mol Sci. 2018. PMID: 29558390 Free PMC article. Review.
681 results