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Discovery of a Potent HIV Integrase Inhibitor that Leads to a Prodrug with Significant anti-HIV Activity.
ACS Med Chem Lett. 2011 Oct 5;2(12):877-881. doi: 10.1021/ml2001246.
ACS Med Chem Lett. 2011.
PMID: 22328963
Free PMC article.
Beta-diketo acids with purine nucleobase scaffolds: novel, selective inhibitors of the strand transfer step of HIV integrase.
Nair V, Uchil V, Neamati N.
Nair V, et al.
Bioorg Med Chem Lett. 2006 Apr 1;16(7):1920-3. doi: 10.1016/j.bmcl.2005.12.093. Epub 2006 Jan 24.
Bioorg Med Chem Lett. 2006.
PMID: 16439124
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A novel strategy to assemble the beta-diketo acid pharmacophore of HIV integrase inhibitors on purine nucleobase scaffolds.
Uchil V, Seo B, Nair V.
Uchil V, et al.
J Org Chem. 2007 Oct 26;72(22):8577-9. doi: 10.1021/jo701336r. Epub 2007 Oct 5.
J Org Chem. 2007.
PMID: 17918897
Free PMC article.
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Biologically-validated HIV integrase inhibitors with nucleobase scaffolds: structure, synthesis, chemical biology, molecular modeling, and antiviral activity.
Nair V, Uchil V, Chi G, Dams I, Cox A, Seo B.
Nair V, et al.
Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):665-8. doi: 10.1080/15257770701490563.
Nucleosides Nucleotides Nucleic Acids. 2007.
PMID: 18066876
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IMPDH as a biological probe for RNA antiviral drug discovery: synthesis, enzymology, molecular docking, and antiviral activity of new ribonucleosides with surrogate bases.
Nair V, Ma X, Shu Q, Zhang F, Uchil V, Cherukupalli GR.
Nair V, et al.
Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):651-4. doi: 10.1080/15257770701490506.
Nucleosides Nucleotides Nucleic Acids. 2007.
PMID: 18066873
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Ribonucleosides bearing Michael acceptors: synthesis, molecular docking, enzyme inhibition data and antiviral activity.
Nair V, Uchil V, Ma X, Zhu Q, Zhang F, Bonsu E.
Nair V, et al.
Nucleic Acids Symp Ser (Oxf). 2008;(52):625-6. doi: 10.1093/nass/nrn316.
Nucleic Acids Symp Ser (Oxf). 2008.
PMID: 18776535
No abstract available.
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