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Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.
Bunnelle WH, Tietje KR, Frost JM, Peters D, Ji J, Li T, Scanio MJ, Shi L, Anderson DJ, Dyhring T, Grønlien JH, Ween H, Thorin-Hagene K, Meyer MD. Bunnelle WH, et al. Among authors: li t. J Med Chem. 2009 Jul 23;52(14):4126-41. doi: 10.1021/jm900249k. J Med Chem. 2009. PMID: 19552432
Synthesis and evaluation of new radioligands [(11)C]A-833834 and [(11)C]A-752274 for positron-emission tomography of α7-nicotinic acetylcholine receptors.
Horti AG, Ravert HT, Gao Y, Holt DP, Bunnelle WH, Schrimpf MR, Li T, Ji J, Valentine H, Scheffel U, Kuwabara H, Wong DF, Dannals RF. Horti AG, et al. Among authors: li t. Nucl Med Biol. 2013 Apr;40(3):395-402. doi: 10.1016/j.nucmedbio.2012.11.013. Epub 2013 Jan 5. Nucl Med Biol. 2013. PMID: 23294899 Free PMC article.
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