Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways.
Pannu J, Nakerakanti S, Smith E, ten Dijke P, Trojanowska M.
Pannu J, et al. Among authors: trojanowska m.
J Biol Chem. 2007 Apr 6;282(14):10405-13. doi: 10.1074/jbc.M611742200. Epub 2007 Feb 15.
J Biol Chem. 2007.
PMID: 17317656
Free article.
Clinical Trial.
The present study utilized previously a described model of scleroderma (SSc) fibrosis based on forced expression of the TGF-betaRI (ALK5) (Pannu, J., Gardner, H., Shearstone, J. R., Smith, E., and Trojanowska, M. (2006) Arthritis Rheum. 54, 3011-3021). This study wa …
The present study utilized previously a described model of scleroderma (SSc) fibrosis based on forced expression of the TGF-betaRI (ALK5) (P …