Little SM - Search Results

1

Synthesis and evaluation of 1-amino-6-halo-β-carbolines as antimalarial and antiprion agents.

Thompson MJ, Louth JC, Little SM, Jackson MP, Boursereau Y, Chen B, Coldham I. Thompson MJ, et al. Among authors: little sm. ChemMedChem. 2012 Apr;7(4):578-86. doi: 10.1002/cmdc.201200002. Epub 2012 Jan 24. ChemMedChem. 2012. PMID: 22275299

2

2,4-diarylthiazole antiprion compounds as a novel structural class of antimalarial leads.

Thompson MJ, Louth JC, Little SM, Chen B, Coldham I. Thompson MJ, et al. Among authors: little sm. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3644-7. doi: 10.1016/j.bmcl.2011.04.090. Epub 2011 Apr 28. Bioorg Med Chem Lett. 2011. PMID: 21570837

3

Application of multicomponent reactions to antimalarial drug discovery. Part 3: discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro.

Musonda CC, Little S, Yardley V, Chibale K. Musonda CC, et al. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4733-6. doi: 10.1016/j.bmcl.2007.06.070. Epub 2007 Jun 27. Bioorg Med Chem Lett. 2007. PMID: 17644333

4

The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives.

Tukulula M, Little S, Gut J, Rosenthal PJ, Wan B, Franzblau SG, Chibale K. Tukulula M, et al. Eur J Med Chem. 2012 Nov;57:259-67. doi: 10.1016/j.ejmech.2012.08.047. Epub 2012 Sep 7. Eur J Med Chem. 2012. PMID: 23064162

5

Synthesis and in vitro protozoocidal evaluation of novel diazabicyclic tropolone derivatives.

Khrizman A, Slack RD, Remsing RC, Little S, Yardley V, Moyna G. Khrizman A, et al. Arch Pharm (Weinheim). 2007 Nov;340(11):569-76. doi: 10.1002/ardp.200700143. Arch Pharm (Weinheim). 2007. PMID: 17924365

6

Synthesis of aminoquinoline-based aminoalcohols and oxazolidinones and their antiplasmodial activity.

Kobarfard F, Yardley V, Little S, Daryaee F, Chibale K. Kobarfard F, et al. Chem Biol Drug Des. 2012 Mar;79(3):326-31. doi: 10.1111/j.1747-0285.2011.01278.x. Epub 2012 Jan 11. Chem Biol Drug Des. 2012. PMID: 22129095

7

Evaluation of azasterols as anti-parasitics.

Gros L, Lorente SO, Jimenez CJ, Yardley V, Rattray L, Wharton H, Little S, Croft SL, Ruiz-Perez LM, Gonzalez-Pacanowska D, Gilbert IH. Gros L, et al. J Med Chem. 2006 Oct 5;49(20):6094-103. doi: 10.1021/jm060290f. J Med Chem. 2006. PMID: 17004723

8

Synthesis, structure, and biological activity of ferrocenyl carbohydrate conjugates.

Ferreira CL, Ewart CB, Barta CA, Little S, Yardley V, Martins C, Polishchuk E, Smith PJ, Moss JR, Merkel M, Adam MJ, Orvig C. Ferreira CL, et al. Inorg Chem. 2006 Oct 2;45(20):8414-22. doi: 10.1021/ic061166p. Inorg Chem. 2006. PMID: 16999442

9

2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.

Singh K, Kaur H, Chibale K, Balzarini J, Little S, Bharatam PV. Singh K, et al. Eur J Med Chem. 2012 Jun;52:82-97. doi: 10.1016/j.ejmech.2012.03.007. Epub 2012 Mar 13. Eur J Med Chem. 2012. PMID: 22459876 Free PMC article.

10

Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents.

Coro J, Atherton R, Little S, Wharton H, Yardley V, Alvarez A Jr, Súarez M, Pérez R, Rodríguez H. Coro J, et al. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1312-5. doi: 10.1016/j.bmcl.2005.11.060. Epub 2005 Dec 15. Bioorg Med Chem Lett. 2006. PMID: 16343898

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