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Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis.
Kanakaraj P, Puffer BA, Yao XT, Kankanala S, Boyd E, Shah RR, Wang G, Patel D, Krishnamurthy R, Kaithamana S, Smith RG, LaFleur DW, Barbas CF 3rd, Hilbert DM, Kiener PA, Roschke VV. Kanakaraj P, et al. Among authors: lafleur dw. MAbs. 2012 Sep-Oct;4(5):600-13. doi: 10.4161/mabs.21227. Epub 2012 Aug 6. MAbs. 2012. PMID: 22864384 Free PMC article.
Monoclonal antibody therapeutics with up to five specificities: functional enhancement through fusion of target-specific peptides.
LaFleur DW, Abramyan D, Kanakaraj P, Smith RG, Shah RR, Wang G, Yao XT, Kankanala S, Boyd E, Zaritskaya L, Nam V, Puffer BA, Buasen P, Kaithamana S, Burnette AF, Krishnamurthy R, Patel D, Roschke VV, Kiener PA, Hilbert DM, Barbas CF 3rd. LaFleur DW, et al. MAbs. 2013 Mar-Apr;5(2):208-18. doi: 10.4161/mabs.23043. MAbs. 2013. PMID: 23575268 Free PMC article.
BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator.
Moore PA, Belvedere O, Orr A, Pieri K, LaFleur DW, Feng P, Soppet D, Charters M, Gentz R, Parmelee D, Li Y, Galperina O, Giri J, Roschke V, Nardelli B, Carrell J, Sosnovtseva S, Greenfield W, Ruben SM, Olsen HS, Fikes J, Hilbert DM. Moore PA, et al. Among authors: lafleur dw. Science. 1999 Jul 9;285(5425):260-3. doi: 10.1126/science.285.5425.260. Science. 1999. PMID: 10398604
Structural and functional characterization of CC chemokine CCL14.
Blain KY, Kwiatkowski W, Zhao Q, La Fleur D, Naik C, Chun TW, Tsareva T, Kanakaraj P, Laird MW, Shah R, George L, Sanyal I, Moore PA, Demeler B, Choe S. Blain KY, et al. Biochemistry. 2007 Sep 4;46(35):10008-15. doi: 10.1021/bi700936w. Epub 2007 Aug 11. Biochemistry. 2007. PMID: 17691823
Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS.
Wu Y, Bressette D, Carrell JA, Kaufman T, Feng P, Taylor K, Gan Y, Cho YH, Garcia AD, Gollatz E, Dimke D, LaFleur D, Migone TS, Nardelli B, Wei P, Ruben SM, Ullrich SJ, Olsen HS, Kanakaraj P, Moore PA, Baker KP. Wu Y, et al. Among authors: lafleur d. J Biol Chem. 2000 Nov 10;275(45):35478-85. doi: 10.1074/jbc.M005224200. J Biol Chem. 2000. PMID: 10956646 Free article.
42 results