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A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites.
Beckham SA, Piedrafita D, Phillips CI, Samarawickrema N, Law RH, Smooker PM, Quinsey NS, Irving JA, Greenwood D, Verhelst SH, Bogyo M, Turk B, Coetzer TH, Wijeyewickrema LC, Spithill TW, Pike RN. Beckham SA, et al. Among authors: quinsey ns. Int J Biochem Cell Biol. 2009 Jul;41(7):1601-12. doi: 10.1016/j.biocel.2009.02.003. Epub 2009 Feb 20. Int J Biochem Cell Biol. 2009. PMID: 19401154 Free PMC article.
The effects of exosite occupancy on the substrate specificity of thrombin.
Ng NM, Quinsey NS, Matthews AY, Kaiserman D, Wijeyewickrema LC, Bird PI, Thompson PE, Pike RN. Ng NM, et al. Among authors: quinsey ns. Arch Biochem Biophys. 2009 Sep;489(1-2):48-54. doi: 10.1016/j.abb.2009.07.012. Epub 2009 Jul 26. Arch Biochem Biophys. 2009. PMID: 19638274
Approaches to selective peptidic inhibitors of factor Xa.
Bromfield KM, Quinsey NS, Duggan PJ, Pike RN. Bromfield KM, et al. Among authors: quinsey ns. Chem Biol Drug Des. 2006 Jul;68(1):11-9. doi: 10.1111/j.1747-0285.2006.00404.x. Chem Biol Drug Des. 2006. PMID: 16923021
Antithrombin: in control of coagulation.
Quinsey NS, Greedy AL, Bottomley SP, Whisstock JC, Pike RN. Quinsey NS, et al. Int J Biochem Cell Biol. 2004 Mar;36(3):386-9. doi: 10.1016/s1357-2725(03)00244-9. Int J Biochem Cell Biol. 2004. PMID: 14687916 Review.
21 results