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Lamotrigine is a substrate for OCT1 in brain endothelial cells.
Dickens D, Owen A, Alfirevic A, Giannoudis A, Davies A, Weksler B, Romero IA, Couraud PO, Pirmohamed M. Dickens D, et al. Among authors: giannoudis a. Biochem Pharmacol. 2012 Mar 15;83(6):805-14. doi: 10.1016/j.bcp.2011.12.032. Epub 2011 Dec 29. Biochem Pharmacol. 2012. PMID: 22227272
Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters.
Davies A, Jordanides NE, Giannoudis A, Lucas CM, Hatziieremia S, Harris RJ, Jørgensen HG, Holyoake TL, Pirmohamed M, Clark RE, Mountford JC. Davies A, et al. Among authors: giannoudis a. Leukemia. 2009 Nov;23(11):1999-2006. doi: 10.1038/leu.2009.166. Epub 2009 Aug 27. Leukemia. 2009. PMID: 19710702 Free article.
The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia.
Giannoudis A, Wang L, Jorgensen AL, Xinarianos G, Davies A, Pushpakom S, Liloglou T, Zhang JE, Austin G, Holyoake TL, Foroni L, Kottaridis PD, Müller MC, Pirmohamed M, Clark RE. Giannoudis A, et al. Blood. 2013 Jan 24;121(4):628-37. doi: 10.1182/blood-2012-01-405035. Epub 2012 Dec 5. Blood. 2013. PMID: 23223357 Free article.
Transport of gabapentin by LAT1 (SLC7A5).
Dickens D, Webb SD, Antonyuk S, Giannoudis A, Owen A, Rädisch S, Hasnain SS, Pirmohamed M. Dickens D, et al. Among authors: giannoudis a. Biochem Pharmacol. 2013 Jun 1;85(11):1672-83. doi: 10.1016/j.bcp.2013.03.022. Epub 2013 Apr 6. Biochem Pharmacol. 2013. PMID: 23567998
44 results