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An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice.
Kinross KM, Montgomery KG, Kleinschmidt M, Waring P, Ivetac I, Tikoo A, Saad M, Hare L, Roh V, Mantamadiotis T, Sheppard KE, Ryland GL, Campbell IG, Gorringe KL, Christensen JG, Cullinane C, Hicks RJ, Pearson RB, Johnstone RW, McArthur GA, Phillips WA. Kinross KM, et al. Among authors: phillips wa. J Clin Invest. 2012 Feb;122(2):553-7. doi: 10.1172/JCI59309. Epub 2012 Jan 3. J Clin Invest. 2012. PMID: 22214849 Free PMC article.
Mutation of the PIK3CA gene in ovarian and breast cancer.
Campbell IG, Russell SE, Choong DY, Montgomery KG, Ciavarella ML, Hooi CS, Cristiano BE, Pearson RB, Phillips WA. Campbell IG, et al. Among authors: phillips wa. Cancer Res. 2004 Nov 1;64(21):7678-81. doi: 10.1158/0008-5472.CAN-04-2933. Cancer Res. 2004. PMID: 15520168
PIK3CA mutations in ovarian cancer.
Campbell IG, Russell SE, Phillips WA. Campbell IG, et al. Among authors: phillips wa. Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):7042; author reply 7042-3. doi: 10.1158/1078-0432.CCR-05-1024. Clin Cancer Res. 2005. PMID: 16203798 No abstract available.
304 results