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An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice.
Kinross KM, Montgomery KG, Kleinschmidt M, Waring P, Ivetac I, Tikoo A, Saad M, Hare L, Roh V, Mantamadiotis T, Sheppard KE, Ryland GL, Campbell IG, Gorringe KL, Christensen JG, Cullinane C, Hicks RJ, Pearson RB, Johnstone RW, McArthur GA, Phillips WA. Kinross KM, et al. Among authors: cullinane c. J Clin Invest. 2012 Feb;122(2):553-7. doi: 10.1172/JCI59309. Epub 2012 Jan 3. J Clin Invest. 2012. PMID: 22214849 Free PMC article.
EGFR blockade with ZD1839 ("Iressa") potentiates the antitumor effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma. Epidermal growth factor receptor.
Solomon B, Hagekyriakou J, Trivett MK, Stacker SA, McArthur GA, Cullinane C. Solomon B, et al. Among authors: cullinane c. Int J Radiat Oncol Biol Phys. 2003 Mar 1;55(3):713-23. doi: 10.1016/s0360-3016(02)04357-2. Int J Radiat Oncol Biol Phys. 2003. PMID: 12573759
Amplicon-dependent CCNE1 expression is critical for clonogenic survival after cisplatin treatment and is correlated with 20q11 gain in ovarian cancer.
Etemadmoghadam D, George J, Cowin PA, Cullinane C, Kansara M; Australian Ovarian Cancer Study Group; Gorringe KL, Smyth GK, Bowtell DD. Etemadmoghadam D, et al. Among authors: cullinane c. PLoS One. 2010 Nov 12;5(11):e15498. doi: 10.1371/journal.pone.0015498. PLoS One. 2010. PMID: 21103391 Free PMC article.
279 results