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RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease.
Fang F, Lue LF, Yan S, Xu H, Luddy JS, Chen D, Walker DG, Stern DM, Yan S, Schmidt AM, Chen JX, Yan SS. Fang F, et al. Among authors: chen jx, chen d. FASEB J. 2010 Apr;24(4):1043-55. doi: 10.1096/fj.09-139634. Epub 2009 Nov 11. FASEB J. 2010. PMID: 19906677 Free PMC article.
We conclude that blockade of microglial RAGE may have a beneficial effect on Abeta-mediated neuronal perturbation relevant to AD pathogenesis.-Fang, F., Lue, L.-F., Yan, S., Xu, H., Luddy, J. S., Chen, D., Walker, D. G., Stern, D. M., Yan, S., Schmidt, …
We conclude that blockade of microglial RAGE may have a beneficial effect on Abeta-mediated neuronal perturbation relevant to AD pathogenesi …
Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease.
Yao J, Du H, Yan S, Fang F, Wang C, Lue LF, Guo L, Chen D, Stern DM, Gunn Moore FJ, Xi Chen J, Arancio O, Yan SS. Yao J, et al. Among authors: chen d. J Neurosci. 2011 Feb 9;31(6):2313-20. doi: 10.1523/JNEUROSCI.4717-10.2011. J Neurosci. 2011. PMID: 21307267 Free PMC article.
Mitochondrial Perturbation in Alzheimer's Disease and Diabetes.
Akhter F, Chen D, Yan SF, Yan SS. Akhter F, et al. Among authors: chen d. Prog Mol Biol Transl Sci. 2017;146:341-361. doi: 10.1016/bs.pmbts.2016.12.019. Epub 2017 Feb 4. Prog Mol Biol Transl Sci. 2017. PMID: 28253990 Free PMC article. Review.
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