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Preclinical evaluation of an inhibitor of cytosolic phospholipase A2α for the treatment of asthma.
Hewson CA, Patel S, Calzetta L, Campwala H, Havard S, Luscombe E, Clarke PA, Peachell PT, Matera MG, Cazzola M, Page C, Abraham WM, Williams CM, Clark JD, Liu WL, Clarke NP, Yeadon M. Hewson CA, et al. Among authors: liu wl. J Pharmacol Exp Ther. 2012 Mar;340(3):656-65. doi: 10.1124/jpet.111.186379. Epub 2011 Dec 7. J Pharmacol Exp Ther. 2012. PMID: 22160268
Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist.
Mowbray CE, Bell AS, Clarke NP, Collins M, Jones RM, Lane CA, Liu WL, Newman SD, Paradowski M, Schenck EJ, Selby MD, Swain NA, Williams DH. Mowbray CE, et al. Among authors: liu wl. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6596-602. doi: 10.1016/j.bmcl.2011.07.125. Epub 2011 Aug 9. Bioorg Med Chem Lett. 2011. PMID: 21920751
Discovery of a series of potent and selective human H4 antagonists using ligand efficiency and libraries to explore structure-activity relationship (SAR).
Masood MA, Selby MD, Bell AS, Mansfield AC, Gardner M, Smith GF, Lane C, Kenyon-Edwards H, Osborne R, Jones RM, Liu WL, Brown CD, Clarke N, Perrucio F, Mowbray CE. Masood MA, et al. Among authors: liu wl. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6591-5. doi: 10.1016/j.bmcl.2011.07.114. Epub 2011 Aug 27. Bioorg Med Chem Lett. 2011. PMID: 21955944
847 results