Hewson CA - Search Results

1

Preclinical evaluation of an inhibitor of cytosolic phospholipase A2α for the treatment of asthma.

Hewson CA, Patel S, Calzetta L, Campwala H, Havard S, Luscombe E, Clarke PA, Peachell PT, Matera MG, Cazzola M, Page C, Abraham WM, Williams CM, Clark JD, Liu WL, Clarke NP, Yeadon M. Hewson CA, et al. J Pharmacol Exp Ther. 2012 Mar;340(3):656-65. doi: 10.1124/jpet.111.186379. Epub 2011 Dec 7. J Pharmacol Exp Ther. 2012. PMID: 22160268

2

A differential role for ceramide kinase in antigen/FcɛRI-mediated mast cell activation and function.

Hewson CA, Watson JR, Liu WL, Fidock MD. Hewson CA, et al. Clin Exp Allergy. 2011 Mar;41(3):389-98. doi: 10.1111/j.1365-2222.2010.03682.x. Epub 2011 Jan 24. Clin Exp Allergy. 2011. PMID: 21255156

3

Design and synthesis of long acting inhaled corticosteroids for the treatment of asthma.

Millan DS, Ballard SA, Chunn S, Dybowski JA, Fulton CK, Glossop PA, Guillabert E, Hewson CA, Jones RM, Lamb DJ, Napier CM, Payne-Cook TA, Renery ER, Selby MD, Tutt MF, Yeadon M. Millan DS, et al. Among authors: hewson ca. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5826-30. doi: 10.1016/j.bmcl.2011.07.106. Epub 2011 Aug 11. Bioorg Med Chem Lett. 2011. PMID: 21880489

4

TAK1 inhibition in the DFG-out conformation.

Kilty I, Green MP, Bell AS, Brown DG, Dodd PG, Hewson C, Hughes SJ, Phillips C, Ryckmans T, Smith RT, van Hoorn WP, Cohen P, Jones LH. Kilty I, et al. Chem Biol Drug Des. 2013 Nov;82(5):500-5. doi: 10.1111/cbdd.12169. Chem Biol Drug Des. 2013. PMID: 23745990

5

A New Series of Orally Bioavailable Chemokine Receptor 9 (CCR9) Antagonists; Possible Agents for the Treatment of Inflammatory Bowel Disease.

Kalindjian SB, Kadnur SV, Hewson CA, Venkateshappa C, Juluri S, Kristam R, Kulkarni B, Mohammed Z, Saxena R, Viswanadhan VN, Aiyar J, McVey D. Kalindjian SB, et al. Among authors: hewson ca. J Med Chem. 2016 Apr 14;59(7):3098-111. doi: 10.1021/acs.jmedchem.5b01840. Epub 2016 Mar 17. J Med Chem. 2016. PMID: 26987013

6

PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-alpha, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms.

Hewson CA, Edbrooke MR, Johnston SL. Hewson CA, et al. J Mol Biol. 2004 Nov 26;344(3):683-95. doi: 10.1016/j.jmb.2004.09.059. J Mol Biol. 2004. PMID: 15533438

7

Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-κB and EGFR pathways.

Hewson CA, Haas JJ, Bartlett NW, Message SD, Laza-Stanca V, Kebadze T, Caramori G, Zhu J, Edbrooke MR, Stanciu LA, Kon OM, Papi A, Jeffery PK, Edwards MR, Johnston SL. Hewson CA, et al. Eur Respir J. 2010 Dec;36(6):1425-35. doi: 10.1183/09031936.00026910. Epub 2010 Jun 4. Eur Respir J. 2010. PMID: 20525715 Free article.

8

Protein kinase R, IkappaB kinase-beta and NF-kappaB are required for human rhinovirus induced pro-inflammatory cytokine production in bronchial epithelial cells.

Edwards MR, Hewson CA, Laza-Stanca V, Lau HT, Mukaida N, Hershenson MB, Johnston SL. Edwards MR, et al. Among authors: hewson ca. Mol Immunol. 2007 Mar;44(7):1587-97. doi: 10.1016/j.molimm.2006.08.014. Epub 2006 Sep 20. Mol Immunol. 2007. PMID: 16989899

9

Toll-like receptor 3 is induced by and mediates antiviral activity against rhinovirus infection of human bronchial epithelial cells.

Hewson CA, Jardine A, Edwards MR, Laza-Stanca V, Johnston SL. Hewson CA, et al. J Virol. 2005 Oct;79(19):12273-9. doi: 10.1128/JVI.79.19.12273-12279.2005. J Virol. 2005. PMID: 16160153 Free PMC article.

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