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Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles.
Brown TJ, Rutland CS, Choi KK, Tse F, Peffers MJ, Mongan NP, Arkill KP, Ritchie A, Clarke PA, Ratan H, Allegrucci C, Grabowska AM, James V. Brown TJ, et al. Among authors: clarke pa. Front Cell Dev Biol. 2024 Feb 22;12:1354606. doi: 10.3389/fcell.2024.1354606. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 38455075 Free PMC article.
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies.
Pasqua AE, Sharp SY, Chessum NEA, Hayes A, Pellegrino L, Tucker MJ, Miah A, Wilding B, Evans LE, Rye CS, Mok NY, Liu M, Henley AT, Gowan S, De Billy E, Te Poele R, Powers M, Eccles SA, Clarke PA, Raynaud FI, Workman P, Jones K, Cheeseman MD. Pasqua AE, et al. Among authors: clarke pa. J Med Chem. 2023 Apr 27;66(8):5907-5936. doi: 10.1021/acs.jmedchem.3c00156. Epub 2023 Apr 5. J Med Chem. 2023. PMID: 37017629 Free PMC article.
Native Size-Exclusion Chromatography-Based Mass Spectrometry Reveals New Components of the Early Heat Shock Protein 90 Inhibition Response Among Limited Global Changes.
Samant RS, Batista S, Larance M, Ozer B, Milton CI, Bludau I, Wu E, Biggins L, Andrews S, Hervieu A, Johnston HE, Al-Lazikhani B, Lamond AI, Clarke PA, Workman P. Samant RS, et al. Among authors: clarke pa. Mol Cell Proteomics. 2023 Feb;22(2):100485. doi: 10.1016/j.mcpro.2022.100485. Epub 2022 Dec 20. Mol Cell Proteomics. 2023. PMID: 36549590 Free PMC article.
Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts.
Sharpe BP, Hayden A, Manousopoulou A, Cowie A, Walker RC, Harrington J, Izadi F, Breininger SP, Gibson J, Pickering O, Jaynes E, Kyle E, Saunders JH, Parsons SL, Ritchie AA, Clarke PA, Collier P, Mongan NP, Bates DO, Yacqub-Usman K, Garbis SD, Walters Z, Rose-Zerilli M, Grabowska AM, Underwood TJ. Sharpe BP, et al. Among authors: clarke pa. Cell Rep Med. 2022 Jun 21;3(6):100541. doi: 10.1016/j.xcrm.2022.100541. Cell Rep Med. 2022. PMID: 35732148 Free PMC article.
Evolution of kinase polypharmacology across HSP90 drug discovery.
Antolin AA, Clarke PA, Collins I, Workman P, Al-Lazikani B. Antolin AA, et al. Among authors: clarke pa. Cell Chem Biol. 2021 Oct 21;28(10):1433-1445.e3. doi: 10.1016/j.chembiol.2021.05.004. Epub 2021 Jun 1. Cell Chem Biol. 2021. PMID: 34077750 Free PMC article.
197 results