Gilissen R - Search Results

1

Pharmacokinetics and pharmacodynamics of TMC207 and its N-desmethyl metabolite in a murine model of tuberculosis.

Rouan MC, Lounis N, Gevers T, Dillen L, Gilissen R, Raoof A, Andries K. Rouan MC, et al. Among authors: gilissen r. Antimicrob Agents Chemother. 2012 Mar;56(3):1444-51. doi: 10.1128/AAC.00720-11. Epub 2011 Dec 12. Antimicrob Agents Chemother. 2012. PMID: 22155815 Free PMC article.

2

Novel antibiotics targeting respiratory ATP synthesis in Gram-positive pathogenic bacteria.

Balemans W, Vranckx L, Lounis N, Pop O, Guillemont J, Vergauwen K, Mol S, Gilissen R, Motte M, Lançois D, De Bolle M, Bonroy K, Lill H, Andries K, Bald D, Koul A. Balemans W, et al. Among authors: gilissen r. Antimicrob Agents Chemother. 2012 Aug;56(8):4131-9. doi: 10.1128/AAC.00273-12. Epub 2012 May 21. Antimicrob Agents Chemother. 2012. PMID: 22615276 Free PMC article.

3

Essentiality of FASII pathway for Staphylococcus aureus.

Balemans W, Lounis N, Gilissen R, Guillemont J, Simmen K, Andries K, Koul A. Balemans W, et al. Among authors: gilissen r. Nature. 2010 Jan 21;463(7279):E3; discussion E4. doi: 10.1038/nature08667. Nature. 2010. PMID: 20090698

4

Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs.

De Buck SS, Sinha VK, Fenu LA, Nijsen MJ, Mackie CE, Gilissen RA. De Buck SS, et al. Drug Metab Dispos. 2007 Oct;35(10):1766-80. doi: 10.1124/dmd.107.015644. Epub 2007 Jul 9. Drug Metab Dispos. 2007. PMID: 17620347

5

Predicting oral clearance in humans: how close can we get with allometry?

Sinha VK, De Buck SS, Fenu LA, Smit JW, Nijsen M, Gilissen RA, Van Peer A, Lavrijsen K, Mackie CE. Sinha VK, et al. Clin Pharmacokinet. 2008;47(1):35-45. doi: 10.2165/00003088-200847010-00004. Clin Pharmacokinet. 2008. PMID: 18076217

6

Prediction of human oral plasma concentration-time profiles using preclinical data: comparative evaluation of prediction approaches in early pharmaceutical discovery.

Van den Bergh A, Sinha V, Gilissen R, Straetemans R, Wuyts K, Morrison D, Bijnens L, Mackie C. Van den Bergh A, et al. Among authors: gilissen r. Clin Pharmacokinet. 2011 Aug;50(8):505-17. doi: 10.2165/11587230-000000000-00000. Clin Pharmacokinet. 2011. PMID: 21740074

7

Towards a better prediction of peak concentration, volume of distribution and half-life after oral drug administration in man, using allometry.

Sinha VK, Vaarties K, De Buck SS, Fenu LA, Nijsen M, Gilissen RA, Sanderson W, Van Uytsel K, Hoeben E, Van Peer A, Mackie CE, Smit JW. Sinha VK, et al. Clin Pharmacokinet. 2011 May;50(5):307-18. doi: 10.2165/11539250-000000000-00000. Clin Pharmacokinet. 2011. PMID: 21456631

8

The prediction of drug metabolism, tissue distribution, and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools.

De Buck SS, Sinha VK, Fenu LA, Gilissen RA, Mackie CE, Nijsen MJ. De Buck SS, et al. Drug Metab Dispos. 2007 Apr;35(4):649-59. doi: 10.1124/dmd.106.014027. Epub 2007 Jan 31. Drug Metab Dispos. 2007. PMID: 17267621

9

Pharmacological profile of JNJ-27141491 [(S)-3-[3,4-difluorophenyl)-propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxyl acid methyl ester], as a noncompetitive and orally active antagonist of the human chemokine receptor CCR2.

Buntinx M, Hermans B, Goossens J, Moechars D, Gilissen RA, Doyon J, Boeckx S, Coesemans E, Van Lommen G, Van Wauwe JP. Buntinx M, et al. J Pharmacol Exp Ther. 2008 Oct;327(1):1-9. doi: 10.1124/jpet.108.140723. Epub 2008 Jul 3. J Pharmacol Exp Ther. 2008. PMID: 18599682

10

Discovery of potent, orally bioavailable small-molecule inhibitors of the human CCR2 receptor.

Doyon J, Coesemans E, Boeckx S, Buntinx M, Hermans B, Van Wauwe JP, Gilissen RA, De Groot AH, Corens D, Van Lommen G. Doyon J, et al. ChemMedChem. 2008 Apr;3(4):660-9. doi: 10.1002/cmdc.200700276. ChemMedChem. 2008. PMID: 18188859

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