Jacobson DA - Search Results

1

Channeling dysglycemia: ion-channel variations perturbing glucose homeostasis.

Denton JS, Jacobson DA. Denton JS, et al. Among authors: jacobson da. Trends Endocrinol Metab. 2012 Jan;23(1):41-8. doi: 10.1016/j.tem.2011.09.004. Epub 2011 Nov 29. Trends Endocrinol Metab. 2012. PMID: 22134088 Free PMC article. Review.

2

G6PC2: a negative regulator of basal glucose-stimulated insulin secretion.

Pound LD, Oeser JK, O'Brien TP, Wang Y, Faulman CJ, Dadi PK, Jacobson DA, Hutton JC, McGuinness OP, Shiota M, O'Brien RM. Pound LD, et al. Among authors: jacobson da. Diabetes. 2013 May;62(5):1547-56. doi: 10.2337/db12-1067. Epub 2012 Dec 28. Diabetes. 2013. PMID: 23274894 Free PMC article.

3

Inhibition of pancreatic β-cell Ca2+/calmodulin-dependent protein kinase II reduces glucose-stimulated calcium influx and insulin secretion, impairing glucose tolerance.

Dadi PK, Vierra NC, Ustione A, Piston DW, Colbran RJ, Jacobson DA. Dadi PK, et al. Among authors: jacobson da. J Biol Chem. 2014 May 2;289(18):12435-45. doi: 10.1074/jbc.M114.562587. Epub 2014 Mar 13. J Biol Chem. 2014. PMID: 24627477 Free PMC article.

4

Direct activation of β-cell KATP channels with a novel xanthine derivative.

Raphemot R, Swale DR, Dadi PK, Jacobson DA, Cooper P, Wojtovich AP, Banerjee S, Nichols CG, Denton JS. Raphemot R, et al. Among authors: jacobson da. Mol Pharmacol. 2014 Jun;85(6):858-65. doi: 10.1124/mol.114.091884. Epub 2014 Mar 19. Mol Pharmacol. 2014. PMID: 24646456 Free PMC article.

5

Pancreatic β-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance.

Dadi PK, Vierra NC, Jacobson DA. Dadi PK, et al. Among authors: jacobson da. Endocrinology. 2014 Oct;155(10):3757-68. doi: 10.1210/en.2013-2051. Epub 2014 Jun 16. Endocrinology. 2014. PMID: 24932805 Free PMC article.

6

Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis.

Vierra NC, Dadi PK, Jeong I, Dickerson M, Powell DR, Jacobson DA. Vierra NC, et al. Among authors: jacobson da. Diabetes. 2015 Nov;64(11):3818-28. doi: 10.2337/db15-0280. Epub 2015 Aug 3. Diabetes. 2015. PMID: 26239056 Free PMC article.

7

G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress.

Boortz KA, Syring KE, Dai C, Pound LD, Oeser JK, Jacobson DA, Wang JC, McGuinness OP, Powers AC, O'Brien RM. Boortz KA, et al. Among authors: jacobson da. Endocrinology. 2016 Aug;157(8):3002-8. doi: 10.1210/en.2016-1245. Epub 2016 Jun 14. Endocrinology. 2016. PMID: 27300767 Free PMC article.

8

Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells.

Dickerson MT, Vierra NC, Milian SC, Dadi PK, Jacobson DA. Dickerson MT, et al. Among authors: jacobson da. PLoS One. 2017 Apr 12;12(4):e0175069. doi: 10.1371/journal.pone.0175069. eCollection 2017. PLoS One. 2017. PMID: 28403169 Free PMC article.

9

TALK-1 channels control β cell endoplasmic reticulum Ca²⁺ homeostasis.

Vierra NC, Dadi PK, Milian SC, Dickerson MT, Jordan KL, Gilon P, Jacobson DA. Vierra NC, et al. Among authors: jacobson da. Sci Signal. 2017 Sep 19;10(497):eaan2883. doi: 10.1126/scisignal.aan2883. Sci Signal. 2017. PMID: 28928238 Free PMC article.

10

Cytokine-mediated changes in K⁺ channel activity promotes an adaptive Ca²⁺ response that sustains β-cell insulin secretion during inflammation.

Dickerson MT, Bogart AM, Altman MK, Milian SC, Jordan KL, Dadi PK, Jacobson DA. Dickerson MT, et al. Among authors: jacobson da. Sci Rep. 2018 Jan 18;8(1):1158. doi: 10.1038/s41598-018-19600-x. Sci Rep. 2018. PMID: 29348619 Free PMC article.

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