Bohn LM - Search Results

1

Structural and functional insights into the G protein-coupled receptors: CB1 and CB2.

Brust CA, Swanson MA, Bohn LM. Brust CA, et al. Among authors: bohn lm. Biochem Soc Trans. 2023 Aug 31;51(4):1533-1543. doi: 10.1042/BST20221316. Biochem Soc Trans. 2023. PMID: 37646476 Free PMC article. Review.

2

A Route to Potent, Selective, and Biased Salvinorin Chemical Space.

Hill SJ, Dao N, Dang VQ, Stahl EL, Bohn LM, Shenvi RA. Hill SJ, et al. Among authors: bohn lm. ACS Cent Sci. 2023 Jul 12;9(8):1567-1574. doi: 10.1021/acscentsci.3c00616. eCollection 2023 Aug 23. ACS Cent Sci. 2023. PMID: 37637743 Free PMC article.

3

Hyperactivity in Mice Induced by Opioid Agonists with Partial Intrinsic Efficacy and Biased Agonism Administered Alone and in Combination with Morphine.

Acevedo-Canabal A, Grim TW, Schmid CL, McFague N, Stahl EL, Kennedy NM, Bannister TD, Bohn LM. Acevedo-Canabal A, et al. Among authors: bohn lm. Biomolecules. 2023 Jun 2;13(6):935. doi: 10.3390/biom13060935. Biomolecules. 2023. PMID: 37371516 Free PMC article.

4

Asymmetric Syntheses of (+)- and (-)-Collybolide Enable Reevaluation of kappa-Opioid Receptor Agonism.

Shevick SL, Freeman SM, Tong G, Russo RJ, Bohn LM, Shenvi RA. Shevick SL, et al. Among authors: bohn lm. ACS Cent Sci. 2022 Jul 27;8(7):948-954. doi: 10.1021/acscentsci.2c00442. Epub 2022 Jul 18. ACS Cent Sci. 2022. PMID: 35912357 Free PMC article.

5

Advances in Sulfonamide Kappa Opioid Receptor Antagonists: Structural Refinement and Evaluation of CNS Clearance.

Ma H, Brust T, Frankowski KJ, Lovell KM, Cameron MD, Bohn LM, Aubé J. Ma H, et al. Among authors: bohn lm. ACS Chem Neurosci. 2022 Apr 20;13(8):1315-1332. doi: 10.1021/acschemneuro.2c00140. Epub 2022 Apr 11. ACS Chem Neurosci. 2022. PMID: 35410469

6

Community guidelines for GPCR ligand bias: IUPHAR review 32.

Kolb P, Kenakin T, Alexander SPH, Bermudez M, Bohn LM, Breinholt CS, Bouvier M, Hill SJ, Kostenis E, Martemyanov KA, Neubig RR, Onaran HO, Rajagopal S, Roth BL, Selent J, Shukla AK, Sommer ME, Gloriam DE. Kolb P, et al. Among authors: bohn lm. Br J Pharmacol. 2022 Jul;179(14):3651-3674. doi: 10.1111/bph.15811. Epub 2022 Mar 27. Br J Pharmacol. 2022. PMID: 35106752 Free PMC article. Review.

7

Improved cyclobutyl nabilone analogs as potent CB1 receptor agonists.

Papanastasiou IP, Georgiadis MO, Iliopoulos-Tsoutsouvas C, Paronis CA, Brust CA, Tran NK, Ji L, Ma X, Wood JT, Zvonok N, Tong F, Bohn LM, Nikas SP, Makriyannis A. Papanastasiou IP, et al. Among authors: bohn lm. Eur J Med Chem. 2022 Feb 15;230:114027. doi: 10.1016/j.ejmech.2021.114027. Epub 2021 Dec 27. Eur J Med Chem. 2022. PMID: 35051750

8

G protein signaling-biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists.

Stahl EL, Schmid CL, Acevedo-Canabal A, Read C, Grim TW, Kennedy NM, Bannister TD, Bohn LM. Stahl EL, et al. Among authors: bohn lm. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2102178118. doi: 10.1073/pnas.2102178118. Proc Natl Acad Sci U S A. 2021. PMID: 34819362 Free PMC article.

9

A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1.

Wang X, Liu D, Shen L, Li F, Li Y, Yang L, Xu T, Tao H, Yao D, Wu L, Hirata K, Bohn LM, Makriyannis A, Liu X, Hua T, Liu ZJ, Wang J. Wang X, et al. Among authors: bohn lm. J Am Chem Soc. 2021 Oct 13;143(40):16320-16325. doi: 10.1021/jacs.1c06847. Epub 2021 Oct 1. J Am Chem Soc. 2021. PMID: 34596399

10

Low Intrinsic Efficacy Alone Cannot Explain the Improved Side Effect Profiles of New Opioid Agonists.

Stahl EL, Bohn LM. Stahl EL, et al. Among authors: bohn lm. Biochemistry. 2022 Sep 20;61(18):1923-1935. doi: 10.1021/acs.biochem.1c00466. Epub 2021 Sep 1. Biochemistry. 2022. PMID: 34468132 Free PMC article. Review.

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