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Phenylalanine-rich peptides potently bind ESAT6, a virulence determinant of Mycobacterium tuberculosis, and concurrently affect the pathogen's growth.
Kumar K, Tharad M, Ganapathy S, Ram G, Narayan A, Khan JA, Pratap R, Ghosh A, Samuchiwal SK, Kumar S, Bhalla K, Gupta D, Natarajan K, Singh Y, Ranganathan A. Kumar K, et al. Among authors: kumar s. PLoS One. 2009 Nov 10;4(11):e7615. doi: 10.1371/journal.pone.0007615. PLoS One. 2009. PMID: 19901982 Free PMC article.
Expression of the ARPC4 subunit of human Arp2/3 severely affects mycobacterium tuberculosis growth and suppresses immunogenic response in murine macrophages.
Ghosh A, Tousif S, Bhattacharya D, Samuchiwal SK, Bhalla K, Tharad M, Kumar S, Prakash P, Kumar P, Das G, Ranganathan A. Ghosh A, et al. Among authors: kumar s, kumar p. PLoS One. 2013 Jul 22;8(7):e69949. doi: 10.1371/journal.pone.0069949. Print 2013. PLoS One. 2013. PMID: 23894563 Free PMC article.
A peptide fragment from the human COX3 protein disrupts association of Mycobacterium tuberculosis virulence proteins ESAT-6 and CFP10, inhibits mycobacterial growth and mounts protective immune response.
Samuchiwal SK, Tousif S, Singh DK, Kumar A, Ghosh A, Bhalla K, Prakash P, Kumar S, Bhattacharyya M, Moodley P, Das G, Ranganathan A. Samuchiwal SK, et al. Among authors: kumar s, kumar a. BMC Infect Dis. 2014 Jul 1;14:355. doi: 10.1186/1471-2334-14-355. BMC Infect Dis. 2014. PMID: 24985537 Free PMC article.
A novel peptide interferes with Mycobacterium tuberculosis virulence and survival.
Samuchiwal SK, Tousif S, Singh DK, Kumar A, Ghosh A, Bhalla K, Prakash P, Kumar S, Trivedi AC, Bhattacharyya M, Das G, Ranganathan A. Samuchiwal SK, et al. Among authors: kumar s, kumar a. FEBS Open Bio. 2014 Aug 7;4:735-40. doi: 10.1016/j.fob.2014.08.001. eCollection 2014. FEBS Open Bio. 2014. PMID: 25349777 Free PMC article.
Host ICAMs play a role in cell invasion by Mycobacterium tuberculosis and Plasmodium falciparum.
Bhalla K, Chugh M, Mehrotra S, Rathore S, Tousif S, Prakash Dwivedi V, Prakash P, Kumar Samuchiwal S, Kumar S, Kumar Singh D, Ghanwat S, Kumar D, Das G, Mohmmed A, Malhotra P, Ranganathan A. Bhalla K, et al. Among authors: kumar samuchiwal s, kumar d, kumar s, kumar singh d. Nat Commun. 2015 Jan 14;6:6049. doi: 10.1038/ncomms7049. Nat Commun. 2015. PMID: 25586702 Free article.
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