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Targeting serpins in high-throughput and structure-based drug design.
Chang YP, Mahadeva R, Patschull AO, Nobeli I, Ekeowa UI, McKay AR, Thalassinos K, Irving JA, Haq I, Nyon MP, Christodoulou J, Ordóñez A, Miranda E, Gooptu B. Chang YP, et al. Among authors: ordonez a. Methods Enzymol. 2011;501:139-75. doi: 10.1016/B978-0-12-385950-1.00008-0. Methods Enzymol. 2011. PMID: 22078534
The serpinopathies studying serpin polymerization in vivo.
Irving JA, Ekeowa UI, Belorgey D, Haq I, Gooptu B, Miranda E, Pérez J, Roussel BD, Ordóñez A, Dalton LE, Thomas SE, Marciniak SJ, Parfrey H, Chilvers ER, Teckman JH, Alam S, Mahadeva R, Rashid ST, Vallier L, Lomas DA. Irving JA, et al. Among authors: ordonez a. Methods Enzymol. 2011;501:421-66. doi: 10.1016/B978-0-12-385950-1.00018-3. Methods Enzymol. 2011. PMID: 22078544
Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody.
Tan L, Perez J, Mela M, Miranda E, Burling KA, Rouhani FN, DeMeo DL, Haq I, Irving JA, Ordóñez A, Dickens JA, Brantly M, Marciniak SJ, Alexander GJ, Gooptu B, Lomas DA. Tan L, et al. Among authors: ordonez a. Int J Biochem Cell Biol. 2015 Jan;58:81-91. doi: 10.1016/j.biocel.2014.11.005. Epub 2014 Nov 13. Int J Biochem Cell Biol. 2015. PMID: 25462157 Free PMC article.
Unravelling the twists and turns of the serpinopathies.
Roussel BD, Irving JA, Ekeowa UI, Belorgey D, Haq I, Ordóñez A, Kruppa AJ, Duvoix A, Rashid ST, Crowther DC, Marciniak SJ, Lomas DA. Roussel BD, et al. Among authors: ordonez a. FEBS J. 2011 Oct;278(20):3859-67. doi: 10.1111/j.1742-4658.2011.08201.x. Epub 2011 Jun 20. FEBS J. 2011. PMID: 21624056 Free article. Review.
An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour.
Motamedi-Shad N, Jagger AM, Liedtke M, Faull SV, Nanda AS, Salvadori E, Wort JL, Kay CW, Heyer-Chauhan N, Miranda E, Perez J, Ordóñez A, Haq I, Irving JA, Lomas DA. Motamedi-Shad N, et al. Among authors: ordonez a. Biochem J. 2016 Oct 1;473(19):3269-90. doi: 10.1042/BCJ20160159. Epub 2016 Jul 12. Biochem J. 2016. PMID: 27407165 Free PMC article.
508 results