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Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design.
Mazella J, Pétrault O, Lucas G, Deval E, Béraud-Dufour S, Gandin C, El-Yacoubi M, Widmann C, Guyon A, Chevet E, Taouji S, Conductier G, Corinus A, Coppola T, Gobbi G, Nahon JL, Heurteaux C, Borsotto M. Mazella J, et al. Among authors: heurteaux c. PLoS Biol. 2010 Apr 13;8(4):e1000355. doi: 10.1371/journal.pbio.1000355. PLoS Biol. 2010. PMID: 20405001 Free PMC article.
Retroinverso analogs of spadin display increased antidepressant effects.
Veyssiere J, Moha Ou Maati H, Mazella J, Gaudriault G, Moreno S, Heurteaux C, Borsotto M. Veyssiere J, et al. Among authors: heurteaux c. Psychopharmacology (Berl). 2015 Feb;232(3):561-74. doi: 10.1007/s00213-014-3683-2. Epub 2014 Aug 2. Psychopharmacology (Berl). 2015. PMID: 25080852 Free PMC article.
Spadin as a new antidepressant: absence of TREK-1-related side effects.
Moha Ou Maati H, Veyssiere J, Labbal F, Coppola T, Gandin C, Widmann C, Mazella J, Heurteaux C, Borsotto M. Moha Ou Maati H, et al. Among authors: heurteaux c. Neuropharmacology. 2012 Jan;62(1):278-88. doi: 10.1016/j.neuropharm.2011.07.019. Epub 2011 Jul 22. Neuropharmacology. 2012. PMID: 21807005
122 results