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Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia.
Yin W, Carballo-Jane E, McLaren DG, Mendoza VH, Gagen K, Geoghagen NS, McNamara LA, Gorski JN, Eiermann GJ, Petrov A, Wolff M, Tong X, Wilsie LC, Akiyama TE, Chen J, Thankappan A, Xue J, Ping X, Andrews G, Wickham LA, Gai CL, Trinh T, Kulick AA, Donnelly MJ, Voronin GO, Rosa R, Cumiskey AM, Bekkari K, Mitnaul LJ, Puig O, Chen F, Raubertas R, Wong PH, Hansen BC, Koblan KS, Roddy TP, Hubbard BK, Strack AM. Yin W, et al. J Lipid Res. 2012 Jan;53(1):51-65. doi: 10.1194/jlr.M019927. Epub 2011 Oct 23. J Lipid Res. 2012. PMID: 22021650 Free PMC article.
Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.
Shen HC, Ding FX, Luell S, Forrest MJ, Carballo-Jane E, Wu KK, Wu TJ, Cheng K, Wilsie LC, Krsmanovic ML, Taggart AK, Ren N, Cai TQ, Deng Q, Chen Q, Wang J, Wolff MS, Tong X, Holt TG, Waters MG, Hammond ML, Tata JR, Colletti SL. Shen HC, et al. J Med Chem. 2007 Dec 13;50(25):6303-6. doi: 10.1021/jm700942d. Epub 2007 Nov 10. J Med Chem. 2007. PMID: 17994679
Pyrazole acids as niacin receptor agonists for the treatment of dyslipidemia.
Schmidt D, Smenton A, Raghavan S, Carballo-Jane E, Lubell S, Ciecko T, Holt TG, Wolff M, Taggart A, Wilsie L, Krsmanovic M, Ren N, Blom D, Cheng K, McCann PE, Gerard Waters M, Tata J, Colletti S. Schmidt D, et al. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4768-72. doi: 10.1016/j.bmcl.2009.06.054. Epub 2009 Jun 17. Bioorg Med Chem Lett. 2009. PMID: 19592242
Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.
Shen HC, Ding FX, Raghavan S, Deng Q, Luell S, Forrest MJ, Carballo-Jane E, Wilsie LC, Krsmanovic ML, Taggart AK, Wu KK, Wu TJ, Cheng K, Ren N, Cai TQ, Chen Q, Wang J, Wolff MS, Tong X, Holt TG, Waters MG, Hammond ML, Tata JR, Colletti SL. Shen HC, et al. J Med Chem. 2010 Mar 25;53(6):2666-70. doi: 10.1021/jm100022r. J Med Chem. 2010. PMID: 20184326
Anthranilic acid replacements in a niacin receptor agonist.
Schmidt D, Smenton A, Raghavan S, Shen H, Ding FX, Carballo-Jane E, Luell S, Ciecko T, Holt TG, Wolff M, Taggart A, Wilsie L, Krsmanovic M, Ren N, Blom D, Cheng K, McCann PE, Waters MG, Tata J, Colletti S. Schmidt D, et al. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3426-30. doi: 10.1016/j.bmcl.2010.04.001. Epub 2010 Apr 8. Bioorg Med Chem Lett. 2010. PMID: 20444602
Altered lipoprotein metabolism in P2Y(13) knockout mice.
Blom D, Yamin TT, Champy MF, Selloum M, Bedu E, Carballo-Jane E, Gerckens L, Luell S, Meurer R, Chin J, Mudgett J, Puig O. Blom D, et al. Biochim Biophys Acta. 2010 Dec;1801(12):1349-60. doi: 10.1016/j.bbalip.2010.08.013. Epub 2010 Sep 15. Biochim Biophys Acta. 2010. PMID: 20817122
ApoA-I mimetic peptides promote pre-β HDL formation in vivo causing remodeling of HDL and triglyceride accumulation at higher dose.
Carballo-Jane E, Chen Z, O'Neill E, Wang J, Burton C, Chang CH, Chen X, Eveland S, Frantz-Wattley B, Gagen K, Hubbard B, Ichetovkin M, Luell S, Meurer R, Song X, Strack A, Langella A, Cianetti S, Rech F, Capitò E, Bufali S, Veneziano M, Verdirame M, Bonelli F, Monteagudo E, Pessi A, Ingenito R, Bianchi E. Carballo-Jane E, et al. Bioorg Med Chem. 2010 Dec 15;18(24):8669-78. doi: 10.1016/j.bmc.2010.09.074. Epub 2010 Nov 4. Bioorg Med Chem. 2010. PMID: 21115285
Reconstituted HDL elicits marked changes in plasma lipids following single-dose injection in C57Bl/6 mice.
Chen Z, O'Neill EA, Meurer RD, Gagen K, Luell S, Wang SP, Ichetovkin M, Frantz-Wattley B, Eveland S, Strack AM, Fisher TS, Johns DG, Sparrow CP, Wright SD, Hubbard BK, Carballo-Jane E. Chen Z, et al. J Cardiovasc Pharmacol Ther. 2012 Sep;17(3):315-23. doi: 10.1177/1074248411426144. Epub 2011 Nov 8. J Cardiovasc Pharmacol Ther. 2012. PMID: 22067613
41 results