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A soluble α-synuclein construct forms a dynamic tetramer.
Wang W, Perovic I, Chittuluru J, Kaganovich A, Nguyen LT, Liao J, Auclair JR, Johnson D, Landeru A, Simorellis AK, Ju S, Cookson MR, Asturias FJ, Agar JN, Webb BN, Kang C, Ringe D, Petsko GA, Pochapsky TC, Hoang QQ. Wang W, et al. Among authors: liao j. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17797-802. doi: 10.1073/pnas.1113260108. Epub 2011 Oct 17. Proc Natl Acad Sci U S A. 2011. PMID: 22006323 Free PMC article.
Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT.
Edayathumangalam R, Wu R, Garcia R, Wang Y, Wang W, Kreinbring CA, Bach A, Liao J, Stone TA, Terwilliger TC, Hoang QQ, Belitsky BR, Petsko GA, Ringe D, Liu D. Edayathumangalam R, et al. Among authors: liao j. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17820-5. doi: 10.1073/pnas.1315887110. Epub 2013 Oct 14. Proc Natl Acad Sci U S A. 2013. PMID: 24127574 Free PMC article.
The Parkinson's disease-associated mutation N1437H impairs conformational dynamics in the G domain of LRRK2.
Huang X, Wu C, Park Y, Long X, Hoang QQ, Liao J. Huang X, et al. Among authors: liao j. FASEB J. 2019 Apr;33(4):4814-4823. doi: 10.1096/fj.201802031R. Epub 2018 Dec 28. FASEB J. 2019. PMID: 30592623 Free PMC article.
Taken together, our data support that conformational dynamics is important for LRRK2 GTPase activity and that the N1437H mutation impairs GTPase activity by locking the ROC domain in a persistently dimeric state.-Huang, X., Wu, C., Park, Y., Long, X., Hoang, Q. Q., Liao, …
Taken together, our data support that conformational dynamics is important for LRRK2 GTPase activity and that the N1437H mutation impairs GT …
In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.
Shima F, Yoshikawa Y, Ye M, Araki M, Matsumoto S, Liao J, Hu L, Sugimoto T, Ijiri Y, Takeda A, Nishiyama Y, Sato C, Muraoka S, Tamura A, Osoda T, Tsuda K, Miyakawa T, Fukunishi H, Shimada J, Kumasaka T, Yamamoto M, Kataoka T. Shima F, et al. Among authors: liao j. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7. doi: 10.1073/pnas.1217730110. Epub 2013 Apr 29. Proc Natl Acad Sci U S A. 2013. PMID: 23630290 Free PMC article.
Structural basis for conformational dynamics of GTP-bound Ras protein.
Shima F, Ijiri Y, Muraoka S, Liao J, Ye M, Araki M, Matsumoto K, Yamamoto N, Sugimoto T, Yoshikawa Y, Kumasaka T, Yamamoto M, Tamura A, Kataoka T. Shima F, et al. Among authors: liao j. J Biol Chem. 2010 Jul 16;285(29):22696-705. doi: 10.1074/jbc.M110.125161. Epub 2010 May 17. J Biol Chem. 2010. PMID: 20479006 Free PMC article.
Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring alpha-helix in conformational dynamics of the GTP-bound Ras family small GTPases.
Matsumoto K, Shima F, Muraoka S, Araki M, Hu L, Ijiri Y, Hirai R, Liao J, Yoshioka T, Kumasaka T, Yamamoto M, Tamura A, Kataoka T. Matsumoto K, et al. Among authors: liao j. J Biol Chem. 2011 Apr 29;286(17):15403-12. doi: 10.1074/jbc.M110.204933. Epub 2011 Mar 9. J Biol Chem. 2011. PMID: 21388959 Free PMC article.
8,004 results