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Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.
Sutherland M, Gill JH, Loadman PM, Laye JP, Sheldrake HM, Illingworth NA, Alandas MN, Cooper PA, Searcey M, Pors K, Shnyder SD, Patterson LH. Sutherland M, et al. Among authors: searcey m. Mol Cancer Ther. 2013 Jan;12(1):27-37. doi: 10.1158/1535-7163.MCT-12-0405. Epub 2012 Oct 1. Mol Cancer Ther. 2013. PMID: 23033491
Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.
Sheldrake HM, Travica S, Johansson I, Loadman PM, Sutherland M, Elsalem L, Illingworth N, Cresswell AJ, Reuillon T, Shnyder SD, Mkrtchian S, Searcey M, Ingelman-Sundberg M, Patterson LH, Pors K. Sheldrake HM, et al. Among authors: searcey m. J Med Chem. 2013 Aug 8;56(15):6273-7. doi: 10.1021/jm4000209. Epub 2013 Jul 26. J Med Chem. 2013. PMID: 23844629 Free article.
Resistance in cancer: a target for drug discovery.
Searcey M, Patterson LH. Searcey M, et al. Curr Med Chem Anticancer Agents. 2004 Sep;4(5):457-60. doi: 10.2174/1568011043352722. Curr Med Chem Anticancer Agents. 2004. PMID: 15379703 Review.
Design and synthesis of a DNA-crosslinking azinomycin analogue.
Casely-Hayford MA, Pors K, James CH, Patterson LH, Hartley JA, Searcey M. Casely-Hayford MA, et al. Among authors: searcey m. Org Biomol Chem. 2005 Oct 7;3(19):3585-9. doi: 10.1039/b508908e. Epub 2005 Sep 5. Org Biomol Chem. 2005. PMID: 16172698
Truncated azinomycin analogues intercalate into DNA.
Casely-Hayford MA, Pors K, Patterson LH, Gerner C, Neidle S, Searcey M. Casely-Hayford MA, et al. Among authors: searcey m. Bioorg Med Chem Lett. 2005 Feb 1;15(3):653-6. doi: 10.1016/j.bmcl.2004.11.037. Bioorg Med Chem Lett. 2005. PMID: 15664831
71 results