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Sphingosine-1-phosphate signaling and its role in disease.
Maceyka M, Harikumar KB, Milstien S, Spiegel S. Maceyka M, et al. Among authors: harikumar kb. Trends Cell Biol. 2012 Jan;22(1):50-60. doi: 10.1016/j.tcb.2011.09.003. Epub 2011 Oct 14. Trends Cell Biol. 2012. PMID: 22001186 Free PMC article. Review.
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.
Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, Luo C, Marmorstein R, Kordula T, Milstien S, Spiegel S. Hait NC, et al. Among authors: harikumar kb. Science. 2009 Sep 4;325(5945):1254-7. doi: 10.1126/science.1176709. Science. 2009. PMID: 19729656 Free PMC article.
A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.
Price MM, Oskeritzian CA, Falanga YT, Harikumar KB, Allegood JC, Alvarez SE, Conrad D, Ryan JJ, Milstien S, Spiegel S. Price MM, et al. Among authors: harikumar kb. J Allergy Clin Immunol. 2013 Feb;131(2):501-11.e1. doi: 10.1016/j.jaci.2012.07.014. Epub 2012 Aug 30. J Allergy Clin Immunol. 2013. PMID: 22939756 Free PMC article.
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.
Liang J, Nagahashi M, Kim EY, Harikumar KB, Yamada A, Huang WC, Hait NC, Allegood JC, Price MM, Avni D, Takabe K, Kordula T, Milstien S, Spiegel S. Liang J, et al. Among authors: harikumar kb. Cancer Cell. 2013 Jan 14;23(1):107-20. doi: 10.1016/j.ccr.2012.11.013. Epub 2012 Dec 27. Cancer Cell. 2013. PMID: 23273921 Free PMC article.
The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses.
Oskeritzian CA, Hait NC, Wedman P, Chumanevich A, Kolawole EM, Price MM, Falanga YT, Harikumar KB, Ryan JJ, Milstien S, Sabbadini R, Spiegel S. Oskeritzian CA, et al. Among authors: harikumar kb. J Allergy Clin Immunol. 2015 Apr;135(4):1008-1018.e1. doi: 10.1016/j.jaci.2014.10.044. Epub 2014 Dec 13. J Allergy Clin Immunol. 2015. PMID: 25512083 Free PMC article.
K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.
Harikumar KB, Yester JW, Surace MJ, Oyeniran C, Price MM, Huang WC, Hait NC, Allegood JC, Yamada A, Kong X, Lazear HM, Bhardwaj R, Takabe K, Diamond MS, Luo C, Milstien S, Spiegel S, Kordula T. Harikumar KB, et al. Nat Immunol. 2014 Mar;15(3):231-8. doi: 10.1038/ni.2810. Epub 2014 Jan 26. Nat Immunol. 2014. PMID: 24464131 Free PMC article.
64 results