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Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells.
Secor JD, Kotha SR, Gurney TO, Patel RB, Kefauver NR, Gupta N, Morris AJ, Haley BE, Parinandi NL. Secor JD, et al. Among authors: patel rb. Int J Toxicol. 2011 Dec;30(6):619-38. doi: 10.1177/1091581811422413. Epub 2011 Oct 12. Int J Toxicol. 2011. PMID: 21994240 Free PMC article.
Pulmonary fibrosis inducer, bleomycin, causes redox-sensitive activation of phospholipase D and cytotoxicity through formation of bioactive lipid signal mediator, phosphatidic acid, in lung microvascular endothelial cells.
Patel RB, Kotha SR, Sherwani SI, Sliman SM, Gurney TO, Loar B, Butler SO, Morris AJ, Marsh CB, Parinandi NL. Patel RB, et al. Int J Toxicol. 2011 Feb;30(1):69-90. doi: 10.1177/1091581810388850. Epub 2010 Dec 3. Int J Toxicol. 2011. PMID: 21131602 Free PMC article.
Thiol-redox antioxidants protect against lung vascular endothelial cytoskeletal alterations caused by pulmonary fibrosis inducer, bleomycin: comparison between classical thiol-protectant, N-acetyl-L-cysteine, and novel thiol antioxidant, N,N'-bis-2-mercaptoethyl isophthalamide.
Patel RB, Kotha SR, Sauers LA, Malireddy S, Gurney TO, Gupta NN, Elton TS, Magalang UJ, Marsh CB, Haley BE, Parinandi NL. Patel RB, et al. Toxicol Mech Methods. 2012 Jun;22(5):383-96. doi: 10.3109/15376516.2012.673089. Toxicol Mech Methods. 2012. PMID: 22409285 Free PMC article.
Phospholipase A(2) activation by poultry particulate matter is mediated through extracellular signal-regulated kinase in lung epithelial cells: regulation of interleukin-8 release.
Kotha SR, Piper MG, Patel RB, Sliman S, Malireddy S, Zhao L, Baran CP, Nana-Sinkam PS, Wewers MD, Romberger D, Marsh CB, Parinandi NL. Kotha SR, et al. Among authors: patel rb. Cell Biochem Biophys. 2013 Nov;67(2):415-29. doi: 10.1007/s12013-011-9329-7. Cell Biochem Biophys. 2013. PMID: 22183614
Adiponectin protects against hyperoxic lung injury and vascular leak.
Sliman SM, Patel RB, Cruff JP, Kotha SR, Newland CA, Schrader CA, Sherwani SI, Gurney TO, Magalang UJ, Parinandi NL. Sliman SM, et al. Among authors: patel rb. Cell Biochem Biophys. 2013 Nov;67(2):399-414. doi: 10.1007/s12013-011-9330-1. Cell Biochem Biophys. 2013. PMID: 22183615 Free PMC article.
Airborne agricultural particulate matter induces inflammatory cytokine secretion by respiratory epithelial cells: mechanisms of regulation by eicosanoid lipid signal mediators.
Malireddy S, Lawson C, Steinhour E, Hart J, Kotha SR, Patel RB, Zhao L, Wilkins JR, Marsh CB, Magalang UJ, Romberger D, Wewers MD, Parinandi NL. Malireddy S, et al. Among authors: patel rb. Indian J Biochem Biophys. 2013 Oct;50(5):387-401. Indian J Biochem Biophys. 2013. PMID: 24772960
Vascular and cardiac impairments in rats inhaling ozone and diesel exhaust particles.
Kodavanti UP, Thomas R, Ledbetter AD, Schladweiler MC, Shannahan JH, Wallenborn JG, Lund AK, Campen MJ, Butler EO, Gottipolu RR, Nyska A, Richards JE, Andrews D, Jaskot RH, McKee J, Kotha SR, Patel RB, Parinandi NL. Kodavanti UP, et al. Among authors: patel rb. Environ Health Perspect. 2011 Mar;119(3):312-8. doi: 10.1289/ehp.1002386. Epub 2010 Oct 27. Environ Health Perspect. 2011. PMID: 20980218 Free PMC article.
Kidney Outcomes Among Medicare Beneficiaries After Hospitalization for Heart Failure.
Ostrominski JW, Greene SJ, Patel RB, Solomon NC, Chiswell K, DeVore AD, Butler J, Heidenreich PA, Huang JC, Kittleson MM, Joynt Maddox KE, Linganathan KK, McDermott JJ, Owens AT, Peterson PN, Solomon SD, Vardeny O, Yancy CW, Fonarow GC, Vaduganathan M. Ostrominski JW, et al. Among authors: patel rb. JAMA Cardiol. 2024 May 29. doi: 10.1001/jamacardio.2024.1108. Online ahead of print. JAMA Cardiol. 2024. PMID: 38809567
338 results