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Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells.
Secor JD, Kotha SR, Gurney TO, Patel RB, Kefauver NR, Gupta N, Morris AJ, Haley BE, Parinandi NL. Secor JD, et al. Among authors: kotha sr. Int J Toxicol. 2011 Dec;30(6):619-38. doi: 10.1177/1091581811422413. Epub 2011 Oct 12. Int J Toxicol. 2011. PMID: 21994240 Free PMC article.
Hyperglycemic oxoaldehyde, glyoxal, causes barrier dysfunction, cytoskeletal alterations, and inhibition of angiogenesis in vascular endothelial cells: aminoguanidine protection.
Sliman SM, Eubank TD, Kotha SR, Kuppusamy ML, Sherwani SI, Butler ES, Kuppusamy P, Roy S, Marsh CB, Stern DM, Parinandi NL. Sliman SM, et al. Among authors: kotha sr. Mol Cell Biochem. 2010 Jan;333(1-2):9-26. doi: 10.1007/s11010-009-0199-x. Epub 2009 Jul 8. Mol Cell Biochem. 2010. PMID: 19585224 Free PMC article.
Vascular and cardiac impairments in rats inhaling ozone and diesel exhaust particles.
Kodavanti UP, Thomas R, Ledbetter AD, Schladweiler MC, Shannahan JH, Wallenborn JG, Lund AK, Campen MJ, Butler EO, Gottipolu RR, Nyska A, Richards JE, Andrews D, Jaskot RH, McKee J, Kotha SR, Patel RB, Parinandi NL. Kodavanti UP, et al. Among authors: kotha sr. Environ Health Perspect. 2011 Mar;119(3):312-8. doi: 10.1289/ehp.1002386. Epub 2010 Oct 27. Environ Health Perspect. 2011. PMID: 20980218 Free PMC article.
Pulmonary fibrosis inducer, bleomycin, causes redox-sensitive activation of phospholipase D and cytotoxicity through formation of bioactive lipid signal mediator, phosphatidic acid, in lung microvascular endothelial cells.
Patel RB, Kotha SR, Sherwani SI, Sliman SM, Gurney TO, Loar B, Butler SO, Morris AJ, Marsh CB, Parinandi NL. Patel RB, et al. Among authors: kotha sr. Int J Toxicol. 2011 Feb;30(1):69-90. doi: 10.1177/1091581810388850. Epub 2010 Dec 3. Int J Toxicol. 2011. PMID: 21131602 Free PMC article.
53 results