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Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo.
Tsoyi K, Lee TY, Lee YS, Kim HJ, Seo HG, Lee JH, Chang KC. Tsoyi K, et al. Among authors: lee ty, lee ys, lee jh. Mol Pharmacol. 2009 Jul;76(1):173-82. doi: 10.1124/mol.109.055137. Epub 2009 Apr 14. Mol Pharmacol. 2009. PMID: 19366789
Stimulation of alpha7 nicotinic acetylcholine receptor by nicotine attenuates inflammatory response in macrophages and improves survival in experimental model of sepsis through heme oxygenase-1 induction.
Tsoyi K, Jang HJ, Kim JW, Chang HK, Lee YS, Pae HO, Kim HJ, Seo HG, Lee JH, Chung HT, Chang KC. Tsoyi K, et al. Among authors: lee ys, lee jh. Antioxid Redox Signal. 2011 Jun;14(11):2057-70. doi: 10.1089/ars.2010.3555. Epub 2011 Mar 17. Antioxid Redox Signal. 2011. PMID: 21083424
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