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Downregulation of CD40 signal and induction of TGF-β by phosphatidylinositol mediates reduction in immunogenicity against recombinant human Factor VIII.
Gaitonde P, Peng A, Straubinger RM, Bankert RB, Balu-Iyer SV. Gaitonde P, et al. Among authors: peng a. J Pharm Sci. 2012 Jan;101(1):48-55. doi: 10.1002/jps.22746. Epub 2011 Sep 23. J Pharm Sci. 2012. PMID: 21953409 Free PMC article.
Factor VIII (FVIII) is an important coagulation cofactor and its deficiency causes Hemophilia A, a bleeding disorder. Replacement therapy using recombinant FVIII is currently the first line of therapy for Hemophilia A, but the development of neutralizing anti …
Factor VIII (FVIII) is an important coagulation cofactor and its deficiency causes Hemophilia A, a bleeding disorder. Replacem …
1,049 results