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Emerging roles of epigenetic mechanisms in Parkinson's disease.
Habibi E, Masoudi-Nejad A, Abdolmaleky HM, Haggarty SJ. Habibi E, et al. Among authors: haggarty sj. Funct Integr Genomics. 2011 Dec;11(4):523-37. doi: 10.1007/s10142-011-0246-z. Epub 2011 Sep 4. Funct Integr Genomics. 2011. PMID: 21892731 Review.
A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.
Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, Ghoshal N, Norton J, Huang Y, Lee SE, Seeley WW, Theofilas P, Grinberg LT, Moreno F, McIlroy K, Boeve BF, Cairns NJ, Crary JF, Haggarty SJ, Ichida JK, Kosik KS, Miller BL, Gan L, Goate AM, Temple S; Tau Consortium Stem Cell Group. Karch CM, et al. Among authors: haggarty sj. Stem Cell Reports. 2019 Nov 12;13(5):939-955. doi: 10.1016/j.stemcr.2019.09.006. Epub 2019 Oct 17. Stem Cell Reports. 2019. PMID: 31631020 Free PMC article.
Advancing drug discovery for schizophrenia.
Marder SR, Roth B, Sullivan PF, Scolnick EM, Nestler EJ, Geyer MA, Welnberger DR, Karayiorgou M, Guidotti A, Gingrich J, Akbarian S, Buchanan RW, Lieberman JA, Conn PJ, Haggarty SJ, Law AJ, Campbell B, Krystal JH, Moghaddam B, Sawa A, Caron MG, George SR, Allen JA, Solis M. Marder SR, et al. Among authors: haggarty sj. Ann N Y Acad Sci. 2011 Oct;1236:30-43. doi: 10.1111/j.1749-6632.2011.06216.x. Ann N Y Acad Sci. 2011. PMID: 22032400 Free PMC article.
Dissecting OGT's TPR domain to identify determinants of cellular function.
Potter SC, Gibbs BE, Hammel FA, Joiner CM, Paulo JA, Janetzko J, Levine ZG, Fei GQ, Haggarty SJ, Walker S. Potter SC, et al. Among authors: haggarty sj. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2401729121. doi: 10.1073/pnas.2401729121. Epub 2024 May 20. Proc Natl Acad Sci U S A. 2024. PMID: 38768345
Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia.
Rosenthal ZC, Fass DM, Payne NC, She A, Patnaik D, Hennig KM, Tesla R, Werthmann GC, Guhl C, Reis SA, Wang X, Chen Y, Placzek M, Williams NS, Hooker J, Herz J, Mazitschek R, Haggarty SJ. Rosenthal ZC, et al. Among authors: haggarty sj. Sci Rep. 2024 Apr 20;14(1):9064. doi: 10.1038/s41598-024-59110-7. Sci Rep. 2024. PMID: 38643236 Free PMC article.
Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with MAPT Mutations.
Bertucci T, Bowles KR, Lotz S, Qi L, Stevens K, Goderie SK, Borden S, Oja LM, Lane K, Lotz R, Lotz H, Chowdhury R, Joy S, Arduini BL, Butler DC, Miller M, Baron H, Sandhof CA, Silva MC, Haggarty SJ, Karch CM, Geschwind DH, Goate AM, Temple S. Bertucci T, et al. Among authors: haggarty sj. bioRxiv [Preprint]. 2023 Jul 11:2023.07.11.548571. doi: 10.1101/2023.07.11.548571. bioRxiv. 2023. PMID: 37503195 Free PMC article. Preprint.
Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca2+ entry and accelerated differentiation.
Hewitt T, Alural B, Tilak M, Wang J, Becke N, Chartley E, Perreault M, Haggarty SJ, Sheridan SD, Perlis RH, Jones N, Mellios N, Lalonde J. Hewitt T, et al. Among authors: haggarty sj. Mol Psychiatry. 2023 Dec;28(12):5237-5250. doi: 10.1038/s41380-023-02152-6. Epub 2023 Jul 4. Mol Psychiatry. 2023. PMID: 37402854 Free PMC article.
A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy.
Eteläinen TS, Silva MC, Uhari-Väänänen JK, De Lorenzo F, Jäntti MH, Cui H, Chavero-Pieres M, Kilpeläinen T, Mechtler C, Svarcbahs R, Seppälä E, Savinainen JR, Puris E, Fricker G, Gynther M, Julku UH, Huttunen HJ, Haggarty SJ, Myöhänen TT. Eteläinen TS, et al. Among authors: haggarty sj. Sci Transl Med. 2023 Apr 12;15(691):eabq2915. doi: 10.1126/scitranslmed.abq2915. Epub 2023 Apr 12. Sci Transl Med. 2023. PMID: 37043557
163 results